Fabrication, bacteriostasis and osteointegration properties researches of the additively-manufactured porous tantalum scaffolds loading vancomycin  

作　　者：Hu Qian Ting Lei Long Hua Yu Zhang Dongyu Wang Jiangyu Nan Wenbin Liu Yan Sun Yihe Hu Pengfei Lei 

机构地区：[1]Department of Orthopedic Surgery,Xiangya Hospital Central South University,Changsha,410008,China [2]Department of Orthopedic Surgery,The First Affiliated Hospital,College of Medicine,Zhejiang University,China [3]Department of Orthopaedic Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi,China [4]Xiangya School of Medicine,Central South University,Changsha,410008,China

出　　处：《Bioactive Materials》2023年第6期450-462,共13页生物活性材料（英文）

基　　金：supported by the Key research and development program of Hunan Province(Grant No.2020SK2008 and 2021GK2012);the Major science and technology projects of Changsha City(Grant No.kh2003016);Clinical research fund of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital,Grant No.2020LNJJ15);The Natural Science Foundation Exploration Project of Zhejiang Province,China(Grant No.Y23H060040);the Natural Science Foundation of Hunan Province,China(Grant No.2022JJ30934).

摘　　要：Infected bone defects(IBDs)remains a challenging problem for orthopedists.Clinically,routine management for IBDs has two stages:debridement and systematic antibiotics administration to control infection,and secondary grafting to repair bone defects.Whereas the efficacy is not satisfactory,because the overuse of antibiotics may lead to systemic toxicity,and the emergence of drug-resistant bacteria,as well as the secondary surgery would cause additional trauma and economic burden to the patients.Therefore,it is imperative to develop a novel scaffold for one-stage repair of IBDs.In this study,vancomycin(Van)was encapsulated into poly(lactic co-glycolic acid)(PLGA)microspheres through the double emulsion method,which were then loaded into the additively-manufactured porous tantalum(AM-Ta)through gelatin methacryloyl(GelMA)hydrogel to produce the composite Ta/GelMA hydrogel(Gel)/PLGA/vancomycin(Van)scaffolds for repairing IBDs.Physiochemical characterization of the newly-developed scaffold indicated that the releasing duration of Van was over 2 weeks.Biological experiments indicated good biocompatibility of the composite scaffold,as well as bacteriostasis and osteointegration properties,which showed great potential for clinical application.The construction of this novel scaffold would provide new sight into the development of orthopaedic implants,shedding a novel light on the treatment of IBDs.

关 键 词：Infected bone defects Porous tantalum PLGA microspheres VANCOMYCIN 

分 类 号：R318[医药卫生—生物医学工程]