兔VX2肝癌模型磁共振张量成像扫描技术初探  

Preliminary Scanning Study of MR Diffusion Tensor Imaging in Rabbit VX2 Liver Tumor Models

作　　者：孙希杰[1] 许乙凯[2] 全显跃[3] 梁文[3] 

机构地区：[1]空军总医院,北京100036 [2]南方医科大学附属南方医院,广州510515 [3]南方医科大学附属珠江医院,广州510282

出　　处：《医疗卫生装备》2008年第5期88-90,共3页Chinese Medical Equipment Journal

基　　金：广东省自然科学基金资助项目(32830)

摘　　要：目的:探讨对兔VX2肝癌模型进行磁共振张量成像(DTI)的可行性及扫描方法。方法:对16只新西兰大白兔的VX2肝癌模型及对照组的4只正常新西兰大白兔进行磁共振成像及DTI;量化分析试验组瘤灶及对照组正常肝组织的平均弥散系数(ADC)、部分各向异性值(FA)随不同b值(b值=100、600、1000 mm2/s)改变的变化规律。结果:兔VX2肝癌模型瘤灶ADC较对照组的正常肝组织减低、瘤灶FA较正常肝组织增高;瘤灶及正常肝组织的ADC、FA均随b值增大而波动减小(P<0.05),组间差异有显著性。结论:DTI能够敏感地显示兔VX2肝癌模型的病变结构;兔VX2肝癌模型的DTI对肝脏病变量化评价的临床应用提供了一定的理论指导。Objective To evaluate the possibility and scan the protocol of diffusion tensor imaging （DTI） in rabbit VX2 liver tumor models. Methods MRI and DTI images were obtained from 16 rabbit VX2 liver tumor models and 4 rabbit control liver models. Average diffusion eoeffieient（ADC ）, fractional anisotropy （FA） of tumors and control livers were estimated and compared with the changing rules （b value=100, 600, 1000 mm^2/s）. Results ADC of tumors had a descending trend and FA of tumors had an increasing trend compared with control livers. The fluctuations of ADC and FA of tumors had a descending trend （P〈0.05）, which had significant differences between control livers. Conclusion DTI can clearly depict the characteristics of rabbit VX2 liver tumor model, and instruct quantitative clinical applications of DTI in theory.

关 键 词：磁共振成像 张量成像 肝脏肿瘤 扫描技术 

分 类 号：R735.7[医药卫生—肿瘤]