贲门癌高/低发区2237例贲门癌患者ABO血型分布  

Distribution of ABO Blood Groups in High and Low Incidence Areas for Gastric Cardia Adenocarcinoma

作　　者：宋昕[1] 王立东[1] 常志伟[1] 常扶保 刘忠[3] 李学民 王苒[1] 范宗民[1] 何欣[1] 陈志国[1] 郭志刚[1] 李江曼[1] 尹艳春[1] 

机构地区：[1]河南省食管癌重点开放实验室郑州大学基础医学院,河南郑州450052 [2]林州市中心医院,河南林州456550 [3]辉县市人民医院病理科,河南辉县453600 [4]磁县医院病理科,河北磁县056500

出　　处：《肿瘤基础与临床》2008年第3期185-188,共4页journal of basic and clinical oncology

基　　金：国家自然科学基金项目(编号:30025016);国家科技部863重大项目(编号:2007);南省医学创新人才工程项目(编号:200084)

摘　　要：目的探讨贲门癌(GCA)高/低发区患者ABO血型的分布特征及其与肿瘤家族史的关系。方法收集河南及其他省市贲门癌高/低发区2 237例患者年龄、性别、籍贯、血型及肿瘤家族史情况,进行统计分析。结果河南省以及其他省贲门癌高/低发区患者不同性别的ABO血型分布差异无统计学意义(P>0.05),男女均为AB型血所占比例最少。贲门癌高发区不同年龄段患者之间ABO血型分布差异无统计学意义(P>0.05)。青年贲门癌患者(<40岁)中A型血所占比例最高(34%),中老年贲门癌患者中B型血者最多,AB型血的患者所占比例最少。肿瘤家族史阳性患者与家族史阴性患者之间的血型分布差异无统计学意义(P>0.05),均为B型血者最多(分别为33%和34%),AB型血所占比例最少(分别为9%和12%),肿瘤家族史阳性患者不同性别的血型分布差异无统计学意义(P>0.05)。肿瘤家族史阳性的不同地区来源的GCA患者血型分布差异无统计学意义(P>0.05)。结论贲门癌患者中以B型血分布最多,A和O血型次之,AB型最少。ABO血型分布与贲门癌家族史阳性无明显相关性。Objective To characterize the relationship between ABO blood groups and gastric cardia adenocarcinoma （GCA） from the high and low incidence areas of GCA in China. Methods Data of age, sex, native place, ABO blood groups and family cancer history of the patients with GCA were collected from Anyang, Linzhou, and Huixian in Henan, Cixia in Hebei, Yanting in Sichuan and Changzhi in Shanxi et al. Of the 2 237 patients with GCA enrolled, 545 patients had positive family cancer history. All the 2 237 patients were retrospectively assessed for their association with ABO blood groups. Results No significant differences were found between ABO blood groups and age, sex, native place, family cancer history for the GCA patients from the high and low incidence areas for GCA （P 〉 0.05）. Conclusions The present results indicate that blood type B has a higher prevalence in GCA patients, however, there is no clear correlation between blood group and positive family history for GCA.

关 键 词：血型 贲门癌 高/低发区 青年贲门癌 家族史 

分 类 号：R730.231[医药卫生—肿瘤] R735.2[医药卫生—临床医学]