立体定向放射治疗非小细胞肺癌脑转移的疗效观察  

The Clinical Observation of the Effect of Fractionated Stereotactic Radiotherapy for Brain Metastasis in Non-Small Cell Lung Cancer

作　　者：樊锐太[1] 张洪志[1] 郭艳娜[1] 王敬敏[1] 顾浩[1] 

机构地区：[1]郑州大学第一附属医院放疗科,河南郑州450052

出　　处：《肿瘤基础与临床》2008年第3期236-238,共3页journal of basic and clinical oncology

摘　　要：目的 探讨全脑放疗加分次立体定向放射治疗（FSRT）对非小细胞肺癌（NSCLC）脑转移的疗效。方法 62例NSCLC脑转移患者接受全脑放疗（WBRT）36～40Gy后行FSRT治疗，放疗结束后行脑部CT或MRI评定疗效。结果 全组62例均按计划完成脑部放疗，治疗后全组总有效率为82．3％；52例治疗前有神经系统症状和体征的患者均有不同程度的改善；中位生存期11个月，1年生存率为43．6％。结论 全脑照射加FSRT治疗NSCLC脑转移有较高的局控率，毒副反应轻，值得推广应用。Objective The aim of this study is to evaluate the therapeutic effect with whole brain radiotherapy （WBRT） and then with fractionated stereotaetic radiotherapy （FSRT） in non-small cell lung cancer （NSCLC） with brain metastasis. Methods A total of 62 NSCLC patients with brain metastasis received FSRT after WBRT to total dose of 36-40 Gy. Response was evaluated by brain CT or MRI after radiotherapy. Results All the patients completed radiotherapy combined with chemotherapy. The objective brain response rate was 82.3%. Symptom relief was observed in all the 52 patients with neurological symptoms. A median survival duration was 11 months. The l-year survival rate was 43.6%. Conclusions WBRT with FSRT is highly effective and well tolerated in treatment of NSCLC with brain metastasis. It may be worthy of further clinical investigation and application.

关 键 词：非小细胞肺癌 脑转移 立体定向放射治疗 疗效 

分 类 号：R730.55[医药卫生—肿瘤] R734.2[医药卫生—临床医学]