晚期非小细胞肺癌患者生活质量和化疗周期数相关性探讨  

The Relativity Between the QOL and the Chemotherapy Cycles of Advanced NSCLC

作　　者：汤良[1] 关玉梅[1] 聂学诚[1] 邢宝华[1] 

机构地区：[1]济宁市第一人民医院肿瘤科,山东济宁273200

出　　处：《肿瘤基础与临床》2008年第3期255-256,共2页journal of basic and clinical oncology

摘　　要：目的 探讨晚期非小细胞肺癌（NSCLC）患者生活质量和化疗周期数的相关性，以确定适当的化疗周期数。方法 给予100例非小细胞肺癌规范性化疗（GP／NP／TC）2～6周期，第1周期化疗前和每周期化疗后2周进行生活质量（quality of life，QOL）随访调查。未能完成6周期者仍在相应时间进行随访。结果 第1周期化疗前评分较低（29分），化疗后提高，化疗4周期后最高（43，5分），之后评分下降，第6周期后降至24分。停止化疗组与继续化疗组同期进行生活质量比较，评分下降较快（19．2分）。结论 晚期NSCLC患者化疗4周期比较适宜。Objective To make the proper chemotherapy cycles by evaluating the relativity between the QOL and chemotherapy cycles. Methods 100 NSCLC patients received 2-6 cycles GP/NP/TC normative chemotherapy and the first cycle and after every cycle for 2 weeks were evaluated. Those who couldn＇ t receive the 6 cycles were evaluated at the same time. Results The QOL improved from 29 score before the first cycle to 43.5 after the 4 cycles, and then fell to 24 after 6 cycles. The QOL in quit chemotherapy group fell to 19.2, less than that in the chemotherapy group. Conclusions 4 chemotherapy cycles are proper to the advance NSCLC patients.

关 键 词：晚期非小细胞肺癌 化疗 周期数 生活质量 

分 类 号：R730.53[医药卫生—肿瘤] R734.2[医药卫生—临床医学]