痔疾洗液体外抑菌、抗滴虫及止痒作用研究  

In Vitro Antibacterial,Trichomonacidal,and Itching-relieving Activities of Hemorrhoids Lotion

作　　者：刘丰丰[1] 青磊[2] 王姗姗[3] 陈伟伟[4] 卢素琳[3] 

机构地区：[1]贵阳医学院附属医院药剂科,贵阳市550004 [2]解放军第44医院,贵阳市550009 [3]贵阳医学院药理学教研室,贵阳市550004 [4]赣南医学院药理学教研室,赣州市341000

出　　处：《中国药房》2008年第15期1133-1134,共2页China Pharmacy

摘　　要：目的:研究痔疾洗液的体外抑菌、抗滴虫及止痒作用。方法:采用液体培养基连续稀释法和体外抑制阴道滴虫试验,观察本品的体外抑菌作用和抗滴虫作用;采用组胺致豚鼠搔痒法观察本品的止痒作用。结果:痔疾洗液对金黄色葡萄球菌、绿脓杆菌、大肠杆菌和白色念珠菌具有抑制作用,对阴道滴虫有杀灭作用;能提高组胺致豚鼠搔痒反应阈值。结论:痔疾洗液具有抑菌、抗阴道滴虫及止痒作用。OBJECTIVE： To study the antibacterial, trichomonacidal, and itching - relieving activities of Hemorrhoids lotion. METHODS： The antibacterial and triehomonacidal activities were detected by serial dilution of liquid medium and trichomonas vaginalis inhibition test in vitro, respectively. The itching- relieving effect of the lotion was observed by using histamine to induce itching of guinea pig. RESULTS： Hemorrhoids lotion inhibited the growth of SA（staphylococcus aureus）, aeruginosus bacillus, escherichia coli and blastomyces albicans, and it had trichomonacidal activity on trichomonas vaginalis; furthermore, it increased the threshold value of histamine-induced itching in guinea pig. CONCLUSION： Hemorrhoids Lotion had antibacterial, trichomonacidal, and itching- relieving activities.

关 键 词：痔疾洗液 抑菌 抗滴虫 止痒 

分 类 号：R285[医药卫生—中药学] R944.12[医药卫生—中医学]