现代电抽搐治疗对精神分裂症兴奋激越行为的影响  

EFFECT OF MODERN ELECTROCONVULSIVE TREATMENT ON OVER-EXCITEMENT IN PATIENTS WITH SCHIZOPHRENIA

作　　者：张少丽[1] 王冠军[1] 潘淑先[1] 

机构地区：[1]青岛市精神卫生中心七病房,山东青岛266034

出　　处：《齐鲁医学杂志》2008年第2期145-146,148,共3页Medical Journal of Qilu

摘　　要：目的观察现代电抽搐治疗（MECT）对精神分裂症兴奋激越行为的疗效。方法将符合CCMD-3精神分裂症诊断标准，且均伴有冲动激越行为的100例病人随机分为A、B两组，分别给予MECT治疗和利培酮并氯硝西泮治疗8周，以阳性症状和阴性症状量表（PANSS）评定临床疗效，副反应量表（TESS）评定副反应。结果治疗1周末，两组PANSS总分、兴奋因子分均显著下降（t=3．223-8．920，P〈0．05）；治疗8周末，A组PANSS量表总分较B组明显下降（t=2．672，P〈0．05），TESS量表评分两组间差异有显著意义（t=6．087，P〈0．05）。结论MECT和利培酮并氯硝西泮治疗均获得很好疗效，MECT更有效且相对安全。Objective To observe the efficacy of modern electroconvulsive treatment （MECT） on over-excitement in patients with schizophrenia. Methods This study consisted of 100 patients with schizophrenia who met the criteria of CCMI-3 and associated with over-excitement were randomly divided into group A and group B. Patients in group A were treated with MECT, and those in group B with risperidone and clonazepam, the course was eight weeks for both groups. The efficacy was evaluated by PANSS and the adverse events by TESS. Results After one week of treatment, the total scores of PANSS and factor-scores of over-excitement were significantly reduced in both groups （t= 3. 223-8. 920,P〈0. 05）. Eight weeks later, the total score of PANSS in group A decreased more significantly than that in group B （t=2. 672,P〈0.05）. Significant difference on the score of TESS was also noted between two groups （t = 6. 087, P〈 0. 05）. Conclusion Compared with risperidone and clonazepam, MECT is better and safer for patients with schizophrenia.

关 键 词：精神分裂症 电刺激疗法 利培酮 氯硝西泮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]