S100A4和E-cadherin在上皮性卵巢肿瘤中的表达及意义  

Expressions of S100A4 and E-cadherin in epithelial ovarian tumor and their significance

作　　者：邢兰瑛[1] 韩志红[1] 刘敏[1] 蔡东阁[1] 方晓荷[1] 

机构地区：[1]西安交通大学医学院第二附属医院妇产科,陕西西安710004

出　　处：《第四军医大学学报》2008年第10期948-951,共4页Journal of the Fourth Military Medical University

摘　　要：目的:研究S100A4蛋白和上皮钙粘蛋白(E-cadher-in,E-cad)在人类上皮性卵巢肿瘤中的表达情况,探讨并分析两者与上皮性卵巢癌的浸润、转移发生的关系及其生物学意义.方法:采用免疫组织化学法SP法检测S100A4蛋白和E-cad在上皮性卵巢肿瘤中的表达与分布,结合临床病理情况分析两者与临床病理参数之间的关系.结果:上皮性卵巢癌中S100A4的表达率比卵巢良性肿瘤和上皮性卵巢交界性肿瘤中的表达率增高(P<0.05);S100A4在上皮性卵巢癌中的表达与组织学分级、有无转移、有无腹水有关(P<0.05),与临床病理分期无关(P>0.05);E-cad在上皮性卵巢癌的表达与临床分期、有无转移、有无腹水有关(P<0.05),而与组织学分级无关(P>0.05);S100A4,E-cad在上皮性卵巢癌中的表达与有无绝经、肿瘤大小、临床病理类型无关(P>0.05);上皮性卵巢癌中S100A4和E-cad的表达呈负相关(r=-0.385,P<0.05).结论:S100A4和E-cad的相关表达与上皮性卵巢癌的发生发展关系密切,是判断上皮性卵巢癌生物学行为、预测侵袭转移的重要指标.AIM：To study the expressions of S100A4 and E-cadherin（E-cad） in human epithelial ovarian tumor, and to explore its roles in ovarian carcinoma invasion and metastasis and its biological significance. METHODS： The expressions of S100A4 and E-cad were detected by S-P immunohistochemistry in histological section of ovarian tumor, and the relationship between the results and clinical pathological parameters were assessed. RESULTS： The expression rate of S100A4 in epithelial ovarian carcinoma was higher than that in borderline cystadenoma and benign tumors and normal ovarian tissues（P 〈0.05）. The expression of S100A4 had a relation with histological grade, metastasis and ascites of the ovarian cancer（P 〈 0. 05 ）, but it had no association with clinical stages（ P 〉 0.05 ）. The expression of E-cad had a relation with clinical stages, metastasis and ascites of the ovarian cancer（ P 〈 0.05 ）, but had no association with histological grade （P 〉 0.05 ）. The expressions of S100A4 and E-cad had no correlation with pathologic types, tumor size and menopause. The negative correlation was observed between S100A4 expression and E-cad expression （ r = - 0. 385, P 〈 0.05 ） CONCLUSION ： The correlated expression of S100A4 and E-cad is closely related to the development of epithelial ovarian carcinoma, which is valuable markers in predicting biological behavior and trend of metastasis in epithelial ovarian carcinoma.

关 键 词：卵巢肿瘤 S100A4 钙粘着糖蛋白类 肿瘤转移 

分 类 号：R737.1[医药卫生—肿瘤]