放射导向手术对肺鳞癌、腺癌胸内转移淋巴结检测的临床价值  

Clinical value of detecting intrathoracic metastatic lymph nodes from squamous cell carcinomas and adenocarcinomas by radioguidance

作　　者：全利国 卢敏[2] 姜学东[1] 胡永校[2] 孟庆显[1] 刘长浩[1] 

机构地区：[1]武警辽宁总队医院胸心外科,沈阳110034 [2]中国医科大学附属第一医院胸外科,沈阳110001

出　　处：《武警医学》2008年第5期438-441,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的采用放射导向手术检测经99mTc-MIBI标记的肺鳞癌、腺癌30例,探讨对肺鳞癌、腺癌胸内转移淋巴结检测的临床价值。方法用放射导向手术探测肺内和纵隔淋巴结及切除的标本,术后对放射导向手术判定为阳性而术后常规病理为阴性的淋巴结,即假阳性进行连续切片、HE染色、显微镜下观察。结果放射导向手术探测淋巴结的灵敏度为100%,特异度96.9%,准确率97.42%。结论放射导向手术比其他检测方法有更高的准确率和更低的漏诊率,能检测出微小的转移淋巴结,以指导外科淋巴结廓清术的进行。Objective To assess the chnical value of detecting intrathoracic metastatic lymph nodes from squamous cell carcinomas and adenocarcinomas by radioguidance.Methods ^99mTc- MIBI labeled lesions were detected by using gamma detecting probe（GDP） in 30 patients with squamous cell carcinomas and adenoeareinomas. After operation, GDP（ ＋ ）,but pathology（ - ）nodes were serially sectioned and HE-stained; some of the sections were iMmnunohistochemically stained for further histopathological study. Results The sensitivity of GDP detection was 100%, the specificity was 96.9%, and the accuracy was 97.42%. Conclusions GDP is more accurate than other means. It indicates tumors and their infiltrative lesions directly and objectively, helps the surgeons to make reasonable choices, and there by improves patients＇ life quality.

关 键 词：放射导向手术 肺鳞癌 腺癌 胸内转移淋巴结 

分 类 号：R734.1[医药卫生—肿瘤]