苦参素注射液治疗慢性丙型肝炎肝硬化合并糖尿病  

Clinic study on the treating of chronic hepatic C and cirrhosis of liver complicated with diabetes mellitus with Matrine and glucose injection

作　　者：许佳平[1] 董梅[1] 黄萃[1] 鲍冰[1] 李纲[1] 努尔陶[1] 

机构地区：[1]武警新疆总队医院感染科,新疆乌鲁木齐830091

出　　处：《武警医学院学报》2008年第5期426-427,430,共3页Acta Academiae Medicinae CPAPF

摘　　要：【目的】探讨苦参素注射液治疗慢性丙型肝炎肝硬化合并糖尿病的效果。【方法】将86例慢性丙型肝炎肝硬化合并糖尿病患者随机分为静滴苦参素治疗组(A组)和基础保肝治疗对照组(B组),疗程均为3个月。【结果】治疗前后肝功能复常率、血糖好转率、HCV-RNA转阴率有明显差别(P<0.05)。肝纤维化指标透明质酸酶(HA)、Ⅲ型前胶原(PCⅢ)治疗后有明显下降(P<0.01),且苦参素治疗组未见明显不良反应。【结论】苦参素注射液对促进肝功能恢复、血糖好转和抑制丙肝病毒复制有一定效果,具有明显的抗纤维化的作用。[Objective] To discuss the results of treating chronic hepatic China and cirvrhosis of liver complicated with diabetus mellitus with marine and diabetes injection. [Methods] 86 patients with chronic hepatitis C or hepatitis cirrhosis were randomly divided into two groups： marine and glucose injection group （group A） and control group （group B）. The time of treatment length were three months. [Results] There was obvious difference in the recovery rates of liver function and growing negative rates of HCV-RNA before and after treatment. （P 〈 0.05）. There was tremendous decrease in HA, PcⅢ after treatment and there was no side-effect in group A. [Conclusions] It is found that better therapeutic effect in promoting liver function, restarting hepatic viruses from replication and controlling hepatic fibrosis.

关 键 词：苦参素注射液 慢性丙型肝炎 肝硬化 糖尿病 

分 类 号：R575.1[医药卫生—消化系统]