头颈癌患者T细胞亚群与白细胞介素2及其受体的动态研究  

Dynamic Observation of T-cell Subsets and Interleukin-2/Soluble Interleukin-2 Receptor in Patients with Head and Neck Carcinoma

作　　者：傅其宏[1] 吴求亮[1] 郭琦[1] 谷志远[1] 刘建华[1] 陈金泉[2] 梁毅[3] 张丽娟[1] 

机构地区：[1]浙江医科大学附属第一医院口腔颌面外科,杭州市310003 [2]浙江医科大学核医学中心 [3]浙江医科大学血液病研究所

出　　处：《中国肿瘤临床》1997年第11期849-852,共4页Chinese Journal of Clinical Oncology

摘　　要：研究对35例头颈癌患者手术前后外周血T细胞亚群、IL－2及sIL－2R表达水平进行了检测，并对其中20例患者进行动态观察。结果显示：头颈癌患者CD；及sIL－2R表达显著增高，比值及IL－2水平明显低于正常人；手术后及sIL－2R表达显菩下降，比位与IL－2水平明显回升；动态观察复发者，比值及IL－2水平再显下降，及sIL－2R表达又见回升。表明：T细胞亚群与IL-2／sIL－2R的检测能反应机体抗肿瘤免疫水平，对监视病情发展、疗效观察及预后判断具有一定的临床价值，动态观察有助于监视肿瘤的复发与转移。Pre-and post-operative peripheral blood T-cell subsets and the serum levels of IL-2/sIL-2R were measured in 35 patients with head and neck cancer and in 20 of them dynamic observations were made. The results showed that the expressions of CD8 and slL-2R significantly increased (P<0. 01 ), while the ratio of CD4/CD8 and the level of IL-2 slgnificantly decreased in patients with head and neck cancer as compared with normal individuals (P<0. 01 ). The above changes were closely rclated to the clinical stages of the tumor except CD4 (P< 0. 05 ).Post-operatively the CD8 and sIL-2R value markedly decreased, while that of CD4/CD8 and IL-2 significantly elevated (p<0.01). The results of dynamic observation were just contrary to the above findings in recurrent patients. lt suggests that obvious abnormality of immunologic ftlnction exis1s in patients with head and neck cancer and that successful surgery may restore the patlent's Immunologic balance.Therefore, detection of T-cell subsets and IL-2/sIL-2R can reflect the immunologic state of the patients, and it might be helpful in assessing therapeutic effect,judging prognosis, monitoring the relapse and metastasis of HNC.

关 键 词：头颈肿瘤 T淋巴细胞亚群 白细胞介素2 受体 

分 类 号：R739.91[医药卫生—肿瘤] R73－37[医药卫生—临床医学]