芳醛-[5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑-2-巯基]-乙酰腙衍生物的合成及生物活性研究  

Synthesis and Bioactivity of Arylaldehyde-[5-(3,4,5-trimethoxy- phenyl)-1,3,4-thiadiazol-2-yl]-thiol Acetyl Hydrazones

作　　者：陈江[1] 刘芳[1] 宋宝安[1] 杨松[1] 胡德禹[1] 金林红[1] 陈卓[1] 薛伟[1] 

机构地区：[1]贵州大学精细化工研究开发中心教育部绿色农药与农业生物工程重点实验室,贵阳550025

出　　处：《有机化学》2008年第5期894-898,共5页Chinese Journal of Organic Chemistry

基　　金：国家973计划(No.2003CB1144004);国家自然科学基金(No.20562002);教育部新世纪优秀人才计划(No.NCET-04-0912);贵州省优秀科技人才资助计划(No.20050515)资助项目

摘　　要：采用活性基团拼接法,以2-巯基-5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑为原料,经硫醚化、肼解、腙化反应合成了8个芳醛-[5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑-2-巯基]-乙酰腙衍生物,并经过元素分析,IR,1H NMR,13C NMR对其结构进行了确认.初步生物活性测试表明,部分化合物具有一定的抑菌生物活性.Eight arylaldehyde-[5-（3,4,5-trimethoxyphenyl）-1,3,4-thiadiazol-2-yl]-acetyl hydrazone derivatives were synthesized with [5-（3,4,5-trimethoxyphenyl）-1,3,4-thiadiazole-2-thiol as starting material according to substructure link principle, followed by thioetherification, hydrazide reaction and hydrazone reaction. The structures of these compounds were determined by elemental analysis, IR, ^1H NMR, and ^13C NMR spectra. Bioassay of the title compounds indicated that some of them exhibited moderate antifungal activity.

关 键 词：酰腙衍生物 1 3 4-噻二唑 合成 抑菌活性 

分 类 号：TQ450.1[化学工程—农药化工]