P21、P53、PCNA在膀胱癌中的表达及意义  

Expression and meaning of P21,P53 and PCNA in bladder cancer

作　　者：张品南[1] 夏作利[1] 郭群[1] 金茹[1] 

机构地区：[1]浙江省温州市第三人民医院,浙江温州325000

出　　处：《现代中西医结合杂志》2008年第17期2606-2607,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的研究同一膀胱癌中癌基因蛋白产物和抗癌基因蛋白产物的表达与增殖活性的临床病理意义。方法应用免疫组织化学En-Vosion法检测5例正常膀胱组织和116例膀胱癌组织中PCNA、P21和P53蛋白的表达水平。结果5例正常膀胱组织中未发现P21、P53和PCNA的表达;116例膀胱癌组织中P21、P53和PCNA阳性检出率分别为62.1%,55.2%和58.6%。P53和PCNA均定位于肿瘤细胞核内,P21蛋白定位于细胞膜上。P21、P53和PCNA阳性表达与膀胱癌的病理分级、临床分期和患者术后生存率关系密切。结论检测P21、P53和PCNA有助于评估膀胱癌的预后。Objective It is to study the expression of cancer gene albumen product and anti-cancer gene albumen product in the same bladder cancer and the clinical pathology meaning of proliferation activity. Methods The expression levels of P21, P53 and PCNA in five cases of normal bladder tissue and 116 cases of bladder cancer tissue were detected with immunohistochemical En - Vosion method. Results There was no expression of P21, P53 and PCNA in five cases of normal bladder tissue. The positive detection rate of P21, P53 and PCNA in 116 cases of bladder cancer tissue was 62.1%, 55.2% and 58.6 % respectively. P53 and PCNA were localized in cell nuclei and P21 was localized on cell membrane in bladder cancer. The expression of P21, P53 and PCNA was correlated to pathology stage, clinical grade and patient postoperative survival rate of bladder cancer. Conclusion The detection of P21, P53 and PCNA maybe used to evaluate the prognosis of bladder cancer.

关 键 词：膀胱肿瘤 癌基因蛋白类 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]