注射用双黄连的免疫毒性研究  

Research of the Immunotoxicity of Shuanghuanglian Injection

作　　者：李瑾翡[1] 黎旸[1] 陈琪[1] 程朝辉[1] 谭舜[1] 

机构地区：[1]广东省药品检验所,广州510180

出　　处：《中药新药与临床药理》2008年第3期172-174,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广东省中医药局科研课题(1040133);广州市科技计划项目(200722-E5061)。

摘　　要：目的观察绿原酸和注射用双黄连的致敏性。方法用豚鼠全身主动过敏反应试验观察注射用双黄连过敏原性;用大鼠、小鼠、豚鼠等同种、异种动物间的被动皮肤过敏反应试验,比较绿原酸和注射用双黄连过敏原性。结果注射用双黄连致敏性高于绿原酸。结论推测注射用双黄连作为一个复方引起不良反应的可能性大于绿原酸。Objective To investigate the allergic reaction of Shuanghuanglian Injection （SI） and chlorogenic acid. Methods The sensitization of SI was evaluated by observed the systemic active allergic reaction on guinea pigs. The homogeneous and heterogenic passive skin allergic reactions in rats, mice and guinea pigs were observed to compare the sensitationz of SI and chlorogenic acid. Results The possibility of SI causing allergic reaction was higher than that of chlorogenic acid. Conclusion It is suggested that the possibility of SI as a compound arising adverse reactions he higher than that of chlorogenic acid.

关 键 词：注射用双黄连 绿原酸 致敏性 

分 类 号：R285.5[医药卫生—中药学]