西酞普兰合用黛力新治疗伴有焦虑症状的抑郁症疗效观察  

Observation of therapeutic effects of citalopram combined deanxit on treating the depressive with anxiety

作　　者：易焕文 李刚[1] 

机构地区：[1]广东省江门市新会区沙堤医院,广东江门529100

出　　处：《中国民康医学》2008年第10期990-991,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:观察西酞普兰合用黛力新治疗伴有焦虑症状的抑郁症的疗效。方法:将57例抑郁症患者随机分成两组,分别为单用西酞普兰组(28例)和西酞普兰合用黛力新组(29例),治疗疗程均为6周,用Hamilton抑郁量表(HAMD)、Hamilton焦虑量表(HAMA)、副反应量表(TESS)评定临床疗效和不良反应。结果:单用西酞普兰组和西酞普兰合用黛力新组总有效率分别为67.8%和86.2%,两组差异有显著性(P<0.05),联合用药组在第一周末HAMD、HAMA减分率均高于单用西酞普兰组,两组差异有显著性(P<0.01),在治疗第6周末联合用药组HAMD分值明显小于单用西酞普兰组(P<0.01),两组不良反应发生率比较差异无显著性(P>0.05)。结论:西酞普兰合用黛力新治疗伴有焦虑症状的抑郁症具有良好的疗效和安全性,且起效快、依从性好。Objetive： To observe the curative effect of treating Depressive with anxiety by combination of Citalopram and Deanxit. Methods： 57 patients with Depressive with anxiety were randomly divided into two groups. One group of 28 patients is treated only by Citalopram for six weeks, the other of 29 patients is treated by combination of Citalopram and Deanxit for the same period. Evaluating the clinical curative effect according to HAMD、HAMA and the safety according to TESS. Results： The total effective rate of the group treated only by Citalopram is 67.8%, while the other is 86.2%. The difference between the two groups is significance （P 〈 0. 05）. The decrease score rate of the group treated by combination of Citalo- pram and Deanxit for one week is much higher than the group only by Citalopram. Moreover the difference is noticeable （P 〈 0.01 ）. The score of HAM D of the group treated by combination of Citalopram and Deanxit for six weeks is much lower than the group of only by Citalopram（ P 〈 0.01）. The difference of the side effects of the two groups is not significance （ P 〉 O. 05 ）. Conclusion： The method of treating Depressive with anxiety by com- bination of Citalopram and Deanxit owns satisfactory curative effect and safety, and it takes effects faster and better compliance.

关 键 词：抑郁症 焦虑症状 西酞普兰 黛力新 

分 类 号：R749.41[医药卫生—神经病学与精神病学]