急性脑梗死后内源性G-CSF和CD34^+细胞动员关系的研究  

The relationship between endogenous G-CSF and CD34^+ cell mobilization after acute cerebral infarction

作　　者：陈小江[1] 许志恩[1] 陈倍楚[1] 

机构地区：[1]广东医学院附属医院神经内科,广东湛江524001

出　　处：《中国老年学杂志》2008年第10期966-969,共4页Chinese Journal of Gerontology

基　　金：广东湛江市科技攻关项目(No.2006C03014)

摘　　要：目的研究急性脑梗死患者发病后自身干细胞(外周血CD34+细胞)及其相关的粒细胞集落刺激因子(G-CSF)水平变化。方法采用对照研究,用流式细胞仪检测健康对照组和急性脑梗死组发病后第1天和第7天中造血干细胞(外周血CD34+细胞),同时用ELISA法检测内源性G-CSF的水平变化。结果急性脑梗死后的第1天和第7天,患者体内外周血CD34+细胞和内源性G-CSF的水平有不同程度的升高,并且患者中外周血CD34+细胞与血清内源性G-CSF水平升高存在正相关(r=0.320)。结论急性脑梗死早期,患者体内外周血CD34+细胞水平和内源性G-CSF水平均升高,并且存在正相关。Objective To probe into the changes of serum hematopoietic stem cell and endogenous G-CSF levels and there relationship in the patient of the acute cerebral infarction （ACI）. Methods By a case-control method, the percentage of circulating hematopoietic stem/the CD34^＋ cells in leukocyte fractions were determined by FACS, the endogenous G-CSF was detected by ELISA between the health individual controls and ACI group. Results The CD34^＋ cells in leukocyte fractions and endogenous G-CSF in ACI group increased at different degree at the I st and 7th day after ACI, presenting positive rectilinear correlation （r = 0. 320）. Conclusions The CD34^＋ cells in leukocyte fractions and endogenous G-CSF in the early after ACI increase, having positive rectilinear correlation.

关 键 词：急性脑梗死 造血干细胞 CD34^+细胞 粒细胞集落刺激因子(G-CSF) 

分 类 号：R-74[医药卫生]