宫颈癌术前新辅助化疗疗效观察  

Subject application of new pre-operation auxiliary chemotherapy in treating cervical carcinoma

作　　者：李艳兵[1] 韩丽丽[2] 李娟[1] 

机构地区：[1]济南市第三人民医院妇科,山东省济南250101 [2]山东省滨州市人民医院妇科

出　　处：《中国基层医药》2008年第4期609-610,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨新辅助化疗（NACT）在子宫颈癌治疗中的作用。方法选择53例宫颈癌患者，所有患者术前均行2个疗程化疗，宫颈鳞癌使用PVB方案（顺铂＋长春新碱＋博来霉素），腺癌使用BIP方案（顺铂十异环磷酰胺＋博来霉素），化疗后2周进行手术根治。结果NACT总有效率为77．4％，其中完全缓解26．4％，部分缓解50．9％，局部肿瘤体积缩小显著，术后病理显示宫旁浸润3．8％，盆腔淋巴结转移7．1％。患者术后恢复良好，常规进行巩固化疗，并进行随访。结论NACT作为宫颈癌愿者术前治疗是安全有效的，可以缩小肿瘤体积，提高手术成功率。Objective To explore the application value of new pre-operation auxiliary chemotherapy（NACT） in treating cervical carcinoma. Methods Two periods of chemotherapy were conducted on 53 cervical carcinoma patients;the chemotherapy projects were PVB and BIP;operation was made two weeks afterwards. Results The total effective rate of NACT was 77.4 % ,26.4 % of which was complete remission; 50.9 % of which was partial remission;local carcinoma bulk decreased significantly; the post-operation pathology indicated that there was 3.8% of uterus infiltration and 7.1% of pelvic cavity lymph node metastasis. Those patients received chemotherapy after the operation,all patients were followed up. Conclusion NACT is safe and effective for the pre-operation treatment of cervical carcinoma, which can reduce the carcinoma bulk and increase the successful rate of the operation.

关 键 词：宫颈肿瘤 化学疗法 辅助 

分 类 号：R737[医药卫生—肿瘤]