呋喃型倍半萜半乳糖碳苷的合成与药理活性  

THE SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF C GALACTOSIDES OF FURANOSESQUITERPENES

作　　者：陈宏明[1,2] 李树春[1,2] 王银叶[1,2] 毛建民[1,2] 蔡孟深[1,2] 贾忠建[1,2] 

机构地区：[1]北京医科大学药学院 [2]兰州大学化学系

出　　处：《药学学报》1997年第10期750-754,共5页Acta Pharmaceutica Sinica

基　　金：北京医科大学天然及仿生药物国家重点实验室基金

摘　　要：利用１Ｏ三氟乙酰基２，３，４，６Ｏ四苄基αＤ吡喃半乳糖分别与７甲氧基６（３戊烯基）３，５二甲基苯并呋喃，７乙酰氧基６（３戊烯基）３，５二甲基苯并呋喃和１，２Ｄｉｈｙｄｒｏｃａｃａｌｏｈａｓｔｉｎ在Ｌｅｗｉｓ酸存在下反应得到四个新的倍半萜碳苷８，９，１０和１１，其结构和组成通过元素分析和波谱方法得以鉴定。药理活性实验结果表明该类倍半萜具有钙拮抗作用，而其碳苷类化合物具有钙激动作用。Four new C galactosides were obtained by the treatment of 1 O trifluoroacetyl 2,3,4,6 tetra O benzyl α D galactopyranose with 7 methoxy 6 (3 pentenyl) 3,5 dimethylbenzofuran, 7 acetoxy 6 (3 pentenyl) 3,5 dimethylbenzofuran and 1,2 dihydrocacalohastin in the presence of Lewis acid. Their structures and compositions were elucidated by elemental analysis and spectroscopic methods. The results of the pharmacological test indicated that the sesquiterpenes are calcium antagonists but their C galactosides are calcium agonists.

关 键 词：呋喃型 倍半萜 碳苷 钙拮抗剂 橐吾属 

分 类 号：R285.5[医药卫生—中药学] R284.3[医药卫生—中医学]