Steroids from the Roots of Asparagus officinalis and Their Cytotoxic Activity  

作　　者：Xue-Feng Huang Yu-Ying Lin Ling-Yi Kong 

机构地区：[1]Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

出　　处：《Journal of Integrative Plant Biology》2008年第6期717-722,共6页植物学报（英文版）

基　　金：the National Natural Science Foundation of China (30701084);the Cultivation Fund of the Key Scientific and Technical Innovation Project, Ministry of Education of China (707033).

摘　　要：One new （Sarsasapogenin O） and seven known steroids were isolated from the roots of Asparagus offlcinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known compounds. These compounds together with nine steroids which were previously isolated from this plant, were tested for cytotoxic activity. Among them, eight compounds displayed significant cytotoxiciUes against human A2780, HO-8910, Eca-109, MGC-803, CNE, LTEP-a-2, KB and mouse L1210 tumor cells.One new （Sarsasapogenin O） and seven known steroids were isolated from the roots of Asparagus offlcinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known compounds. These compounds together with nine steroids which were previously isolated from this plant, were tested for cytotoxic activity. Among them, eight compounds displayed significant cytotoxiciUes against human A2780, HO-8910, Eca-109, MGC-803, CNE, LTEP-a-2, KB and mouse L1210 tumor cells.

关 键 词：Asparagus officinalis cytotoxic activity Sarsasapogenin O STEROID 

分 类 号：R285[医药卫生—中药学]