Decreased postprandial gallbladder emptying in patients with black pigment stones  

作　　者：Takakazu Sugo Kenichi Hakamada Shunji Narumi Mutsuo Sasaki 

机构地区：[1]Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan

出　　处：《World Journal of Gastroenterology》2008年第18期2825-2831,共7页世界胃肠病学杂志（英文版）

摘　　要：AIM: To analyze gallbladder contractility in patients with black pigment stones (BPSs) and to compare this with patients with cholesterol stones (CSs) and healthy volunteers. METHODS: The pattern of bile evacuation from the gallbladder was quantified by computer cholescintigraphy in 28 normal subjects, 22 patients with CSs and 14 with BPSs. The parameters of gallbladder contractility included ejection period (EP), ejection fraction (EF) and ejection rate (ER). RESULTS: A significantly shorter EP was observed in patients with BPSs in comparison to those with CSs (t = 2.4, P < 0.05). EF in BPS patients significantly decreased in comparison to that in CS and normal subjects (t = 6.4, P < 0.0001; t = 2.1, P < 0.05). EF in CS patients also significantly decreased in comparison to that in normal subjects (t = -3.0, P < 0.005). Consequently, ER in patients with BPSs and CSs was significantly smaller than that in normal subjects (t = 3.1, P < 0.005; t = -3.5, P < 0.001). Moreover, in cases where postprandial reflux of a radioisotope into the common hepatic duct from the gallbladder was observed, EF and ER of either CS or BPS patients showed a significant reduction. CONCLUSION: Bile evacuation from the gallbladder is reduced in patients with BPSs, in comparison to those with CSs and to healthy volunteers. Bile stagnation due to impaired gallbladder kinetics seems to be one of the predisposing factors for the development of BPSs.AIM： To analyze gallbladder contractility in patients with black pigment stones （BPSs） and to compare this with patients with cholesterol stones （CSs） and healthy volunteers. METHODS： The pattern of bile evacuation from the gallbladder was quantified by computer cholescintigraphy in 28 normal subjects, 22 patients with CSs and 14 with BPSs. The parameters of gallbladder contractility included ejection period （EP）, ejection fraction （EF） and ejection rate （ER）. RESULTS： A significantly shorter EP was observed in patients with BPSs in comparison to those with CSs （t = 2.4, P 〈 0.05）. EF in BPS patients significantly decreased in comparison to that in CS and normal subjects （t = 6.4, P 〈 0.0001; t = 2.1, P 〈 0.05）. EF in CS patients also significantly decreased in comparison to that in normal subjects （t = -3.0, P 〈 0.005）. Consequently, ER in patients with BPSs and CSs was significantly smaller than that in normal subjects （t = 3.1, P 〈 0.005; t = -3.5, P 〈 0.001）. Moreover, in cases where postprandial reflux of a radioisotope into the common hepatic duct from the gallbladder was observed, EF and ER of either CS or BPS patients showed a significant reduction. CONCLUSION： Bile evacuation from the gallbladder is reduced in patients with BPSs, in comparison to those with CSs and to healthy volunteers. Bile stagnation due to impaired gallbladder kinetics seems to be one of the predisposing factors for the development of BPSs.

关 键 词：Black pigment stone Cholescintigraphy Gallbladder emptying Ejection period Ejection fraction Ejection rate 

分 类 号：R575.62[医药卫生—消化系统]