紫绀型先心病术中乳酸及氧代谢变化  

Chance of lactate and oxygen metabolism during cardiopulmonary bypass operation of children

作　　者：付春梅[1] 卢赛兰[1] 何素丽[1] 

机构地区：[1]广东省汕头市汕头大学医学院第一附属医院,515144

出　　处：《中国实用医药》2008年第15期62-64,共3页China Practical Medicine

摘　　要：目的通过体外循环（CPB）期间乳酸及氧代谢指标的变化,探明CPB期间组织氧代谢的状况。方法6-10岁紫绀先心病患儿10例,于手术开始前、CPB前1-3s、CPB30s、复温34℃、CPB停止后1-3s、术毕,6个时点取动、静脉血测Hb、SaO2、PaO2、SvO2、PvO2及动脉乳酸值。结果CPB开始后乳酸值开始升高,复温时乳酸达峰值,以后渐渐回落。转流30s、复温34℃、停机,术毕的乳酸值与手术开始前相对比均差异有统计学意义（P〈0.05）。结论CPB期间机体存在着组织摄氧能力下降,应改善微循环,给予充足的氧供。Objective To explore the tissue oxygen metabolism during cardiopulmonary bypass operation of children, through the chance of plasma lactate and tissue oxygen metabolism.Methods Ten children with cyanosi congenital disease,between 6-10years,Arterial and mixed venous blood gas, and blood lactate lever were measured before operation,before CPB, after CPB30＇,rewarming 34℃, after CPB1-3＇ and ending operation.Results After CPB, the plasma lactate level increased gradually,was the highest in rewarming 34℃, then slowly reduced.The change of lactate was significant higher in CPB30＇（P〈0.01）,in rewarming34℃,after CPB（1-3 s）and in end of operation than before operation and before CPB（P〈0.05）.Conclusion The increase of the level of plasma lactate during CPB indicated decrease of tissue intaking oxygen;it was necessary that there was full oxygen supply during CPB.

关 键 词：体外循环 乳酸 氧代谢 

分 类 号：R726.5[医药卫生—儿科]