Electrochemical study of the effect of functionalized nickel nanoparticles on cellular uptake of leukemia cancer cells in vitro  

作　　者：Da Dong Guo Chun Hui Wu Xue Mei Wang Bao An Chen 

机构地区：[1]State Key Lab of Bioelectronics （Chien-Shiung Wu Lab）, Southeast University, Nanjing 210096, China [2]Zhongda Hospital, School of Clinical Medical, Southeast University, Nanjing 210096, China

出　　处：《Chinese Chemical Letters》2008年第5期577-580,共4页中国化学快报（英文版）

摘　　要：In this study, we have fabricated the functionalized nickel nanoparticles and investigated their effects on cellular uptake of quercetin in leukemia K562 cancer cells by using electrochemical assay. The results indicate that nickel nanoparticles could efficiently enhance the quercetin uptake and increase the intracellular accumulation in cancer cells, implying the great potential of functionalized nickel nanoparticles in target cancer therapy.In this study, we have fabricated the functionalized nickel nanoparticles and investigated their effects on cellular uptake of quercetin in leukemia K562 cancer cells by using electrochemical assay. The results indicate that nickel nanoparticles could efficiently enhance the quercetin uptake and increase the intracellular accumulation in cancer cells, implying the great potential of functionalized nickel nanoparticles in target cancer therapy.

关 键 词：Nickel nanoparticles Leukemia cancer cells QUERCETIN Electrochemical assay 

分 类 号：R733.7[医药卫生—肿瘤]