丹参治疗大鼠肝纤维化的效果观察  

Observation on the therapeutic Effects of Hepatic Fibrosis of Rats with Salvia Miltiorrhiza

作　　者：张晓燕[1] 舒建昌[1] 何雅军[2] 叶国荣[1] 吕霞[1] 

机构地区：[1]广州市红十字会医院消化内科,广州510220 [2]广州市红十字会医院检验科,广州510220

出　　处：《国际中医中药杂志》2008年第3期172-173,共2页International Journal of Traditional Chinese Medicine

基　　金：基金项目：2004年度广东省中医药局科研课题（编号：1040147）：2004年广州市卫生局中医药、中西医结合立项科研课题（编号：2004A041）

摘　　要：目的观察丹参治疗四氯化碳所致大鼠肝纤维化的效果。方法采用四氯化碳腹腔注射法制作大鼠肝纤维化模型，给予丹参灌胃处理，同时设立正常组、对照组，检测血清丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、透明质酸（HA）、层黏连蛋白（LN）、Ⅲ型前胶原（PC-Ⅲ），肝组织行HE和Masson三色胶原染色，光镜下观察肝脏组织病理学变化。结果较模型组，丹参组能明显降低肝纤维化时异常升高的ALT、AST、HA、LN、PC-Ⅲ（P〈0．01），明显改善四氯化碳所致大鼠肝纤维化的病理学改变。结论丹参具有治疗大鼠肝纤维化作用。Objective To investigate therapeutic effects of Salvia miltiorrhiza on hepatic fibrosis of rats induced by carbon tetrachloridean. Methods Rat models of hepatic fibrosis were founded by intraperitoneal injection of carbon tetrachloride. Salvia miltiorrhiza were given to these rats. Normal group and control group were set for comparison at the same time. Serum levels of ALT, AST, HA, LN, and PC-Ⅲ were detected; HE and Masson staining were conducted in hepatic tissues to observe pathological variations. Results Salvia miltiorrhiza could decrease serum levels of ALT, AST, HA, LN, PC-Ⅲ obviously （P 〈0.01）, compared with the control group; Salvia miltiorrhiza could obviously improve pathological variations compared with the control group. Conclusion Salvia miltiorrhiza has therapeutic effect on hepatic fibrosis of rats

关 键 词：丹参 肝纤维化 治疗 

分 类 号：R575.2[医药卫生—消化系统]