激光照射参数对光动力学疗法治疗眼底病中视网膜温度影响的理论分析  

Influence of Laser Parameters on Temperature Distribution of Retina:a Theoretical Analysis

作　　者：陈虹霞[1] 顾瑛[1] 程刚[2] 刘凡光[1] 曾晶[1] 

机构地区：[1]解放军总医院激光医学科,北京市100853 [2]北京理工大学自动化控制系

出　　处：《中国激光医学杂志》2008年第2期89-93,共5页Chinese Journal of Laser Medicine & Surgery

基　　金：北京市自然科学基金(3072012)

摘　　要：目的了解不同激光照射参数对光动力学疗法治疗眼底疾病中视网膜温度的影响。方法根据经典Pennls热传输方程建立视网膜温度分布的数学模型,理论分析激光波长、功率密度及光斑直径对光动力学疗法治疗过程中对青紫蓝灰兔视网膜温度的影响。结果当照光剂量相同时,578 nm激光引起的灰兔视网膜温升最大,532 nm激光次之,690 nm激光最小;随着激光功率密度及光斑直径的增加,视网膜温升也越高。结论光动力学疗法治疗中严格控制照光参数对于防止不必要的视网膜热损伤非常重要。Objective To investigate the influence of the different laser therapeutic parameters on the temperature distribution of retina in photodynamic therapy on ocular fundus diseases. Methods The influence of laser wavelength, power density and spot diameter on retina of chinchilla grey rabbits was analyzed theoretically using the mathematical model established by us based on classical bio-heat transfer model-Pennes equation. Results The results showed that laser wavelength, power density and spot diameter were important factors to affect temperature distribution. The temperature induced by 578 nm laser was the highest, and 532nm laser was next to it. The temperature induced by 690 nm laser was the minimum. With increasing in the power density and the spot diameter, retinal temperature raises too. Conclusions To prevent unwanted thermal damage, we must control strictly the laser parameters during photodynamic therapy on fundus diseases.

关 键 词：光动力学疗法 视网膜 温度分布 数学模拟 

分 类 号：R774.1[医药卫生—眼科]