乳腺癌钼靶X线钙化与HER-2／neu表达的关系及其意义  

Correlation between mammographic calcifications and HER-2/neu overexpression in breast carcinoma

作　　者：王晓[1] 陈连胜[1] 田斌[1] 孙涛[1] 金广超[1] 马国辉[1] 臧益秀[1] 孙靖中[2] 

机构地区：[1]山东大学医学院济南市中心医院乳腺外科,山东济南250013 [2]山东大学齐鲁医院乳腺外科,山东济南250012

出　　处：《中国普通外科杂志》2008年第5期436-439,共4页China Journal of General Surgery

摘　　要：目的探讨乳腺癌钼靶X线钙化与HER-2/neu表达的关系及其临床意义。方法分析152例乳腺癌钼靶X线片的钙化特点;并将切除的肿瘤标本行HER-2/neu检测,分析钼靶X线钙化特征与HER-2/neu表达之间的关系。结果乳腺癌钼靶X线钙化组HER-2/neu过度表达率高于无钙化组(61.6%vs.35.4%)(P<0.01);在73例钙化中,以钙化伴随毛刺征为主要表现者,HER-2/neu过度表达率高于单纯钙化组(P<0.05)。根据钙化形态特征,蠕虫状钙化组HER-2/neu过度表达率明显高于非蠕虫状钙化组(P=0.01)。钼靶X线钙化簇最大径≥25 mm者,多在HER-2/neu过度表达组(P<0.05),而钙化颗粒数≤20枚/cm2者,多在HER-2/neu阴性表达组(P<0.01)。结论乳腺癌钼靶X线钙化与HER-2/neu过度表达关系密切,可为乳腺癌治疗策略的制定和预测预后提供参考。Objective To evaluate the correlation between mammographic calcifications and HER-2/neu overexpression in breast carcinomas （BC） and its clinical significance. Methods A retrospective study of preoperative mammograms in patients with breast carcinoma, and immunohistochemical staining of excised tumor specimens was carried out by using monoclonal antibody against HER-2/neu in 152 patients with BC to evaluate the correlation of mammagraphic calcifications with HER-2/neu overexpression. Results There was a significant correlation between mammographic calcifications and HER-2/neu overexpression （P 〈 0.01 ）. In the 73 cases of carcinoma with calcifications on mammagraphy, HER-2/neu overexpression was statistically higher in calcifications associated spiculated mass than in simple calcifications （P 〈 0.05 ）. According to morphologic aspects of calcifications, vermicular calcifications were more common in carcinomas with HER-2/neu overexpression than in those without HER-2/neu overexpression （P = 0. 01 ）. The carcinomas with calcifications ≥25 mm in diameter were much more commonly associated with HER-2/neu overexpression （ P 〈 0.05 ） , whereas the number of calcifications less than 20/cm2 was more common in HER-2/neu negative expression （ P 〈 0.01 ） . Conclusions Mammographic calcifications are significantly correlated with HER-2/neu overexpression and may offer reference for planning a therapeutic stategy and predicting prognosis of breast cancer.

关 键 词：乳腺肿瘤/放射摄影术 乳房X线摄影术 钙化 HER-2/NEU 

分 类 号：R737.9[医药卫生—肿瘤]