子宫内膜癌患者孕激素受体B基因甲基化状态分析  

The methylation analysis of progesterone receptor B gene in human uterine endometrial cancer

作　　者：吴炳坤 朱斌[2] 高锦声[2] 

机构地区：[1]浙江省桐庐县中医院检验科,浙江桐庐311500 [2]苏州大学医学遗传研究室,江苏苏州215123

出　　处：《中国优生与遗传杂志》2008年第6期27-28,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨子宫内膜癌患者孕激素受体B基因CpG岛甲基化状态改变及其与肿瘤发生的关系。方法采用甲基化特异性PCR技术检测32例子宫内膜癌患及28例正常对照石蜡包埋标本孕激素受体B基因CpG岛甲基化状态。结果中国子宫内膜癌患者孕激素受体B基因异常甲基化发生率达66.7%,而28例正常对照标本没有发现甲基化异常。结论孕激素受体B基因甲基化可能与子宫内膜癌发生发展密切相关。Objective： To investigate the methylation changes of progesterone receptor B gene in uterine endometrial cancer and its relation with tumorigenesis. Methods： By using methylation - specific polymerase chain reaction （MSP） method, the methylation status of progesterone receptor B gene were analysed from paraffin - imbedded samples of 32 patients and 28 normal controls. Results ： Progesterone receptor B gene showed abrrent methylation in 66. 7% patients , but none in normal controls. Conclusion ： Progesterone receptor B gene methylation might be related with pathogenesis of uterine endometrial cancer.

关 键 词：子宫内膜癌 孕激素受体B基因 甲基化 CPG岛 

分 类 号：R737.33[医药卫生—肿瘤]