DMBT1、E-cadherin在食管鳞癌中的表达及其生物学意义  

Expression and biological significance of DMBT1,E-cadherin in esophageal squamous carcinoma

作　　者：罗文彦[1] 左连富[2] 李子良[1] 成媛[1] 张梁[1] 

机构地区：[1]石家庄卫生学校病理教研室,河北石家庄050200 [2]河北医科大学第四医院肿瘤研究所,河北石家庄050011

出　　处：《现代肿瘤医学》2008年第6期1001-1003,共3页Journal of Modern Oncology

摘　　要：目的:探讨食管鳞癌组织中抑癌基因DMBT1以及粘附分子E-cadherin的表达及其与肿瘤生物学行为的关系。方法:应用免疫组织化学方法检测70例食管鳞癌组织,23例切缘正常组织中DMBT1、E-cad-herin的表达情况。结果:DMBT1、E-cadherin在癌组织中的表达减弱或呈阴性。DMBT1、E-cadherin的表达与食管鳞癌组织的分化程度、淋巴结的转移有关(P<0.05),与癌组织的浸润深度无关(P>0.05)。结论:DMBT1、E-cadherin的表达减弱是食管鳞癌组织低分化和高度恶性的生物学标志,并与淋巴结的转移密切相关。Objective：To investigate the expression of DMBT1, E - cadherin in esophageal squamous carcinoma and the relationship to biological behavior of tumors. Methods：The expression of DMBT1 and E - cadherin was examined by immunohistochemistry （IHC） in 70 cases of esophageal squamous carcinoma and 23 cases of incisal margin normal tissues. Results ：The expression of DMBT1 and E- cadherin in esophageal squamous carcinoma was weak or negative. The expression of DMBT1 and E - cadherin was related with histological differentiation degree, lymph node metastasis （P 〈 0.05）. Conclusion ： Weak or negative expression of DMBT1 and E - cadherin could be a biological markers of poor differention , high malignancy and lymph node metastasis of esophageal squamous carcinoma.

关 键 词：食管鳞癌 DMBTl E-CADHERIN 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]