Caveolin-1在血管生成中的作用  

Role of caveolin-1 in angiogenesis

作　　者：房凯[1] 姜懿凌[2] 赵雨杰[1] 

机构地区：[1]中国医科大学基础医学院生物信息学教研室,辽宁沈阳110001 [2]中国医科大学

出　　处：《现代肿瘤医学》2008年第6期1053-1054,共2页Journal of Modern Oncology

摘　　要：Caveolin-1是细胞膜表面内陷结构Caveolae的标志性蛋白,识别并与多种信号蛋白分子相作用,在内皮细胞内表达量较高,在血管内皮细胞增殖、迁移和分化过程中具有重要作用,在小鼠动物模型中对血管生成、肿瘤生长起抑制作用,有可能成为抑制肿瘤血管生成的靶蛋白。Caveolin -1 is the marker protein of caveolae, expresses abundantly in endothelial cells , recognizes and interacts with many signal protein kinases, and thus play an important role in endothelial cells proliferation, migration and differentiation in vitro. The caveolin - 1 transgenic and knockout mouse investigations showed that caveolin - 1 inhibits angiogenesis and may be a target for angiogenesis.

关 键 词：CAVEOLIN-1 血管生成 内皮细胞 肿瘤 

分 类 号：R730.3[医药卫生—肿瘤]