促凋亡基因p53AIP1的研究进展  

Research Advances in Proapoptosis Gene p53AIP1

作　　者：姜云波[1] 陆应麟[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850

出　　处：《生物技术通讯》2008年第3期427-429,共3页Letters in Biotechnology

摘　　要：p53AIP1基因是近年发现的促凋亡基因,在p53依赖性的凋亡通路中起重要作用。p53AIP1介导线粒体凋亡途径,其表达依赖于p53蛋白的Ser46的磷酸化。p53AIP1可直接促进凋亡,其促凋亡作用可能强于p53本身,并对p53抗性的肿瘤细胞也有作用。因此,对p53AIP1的深入研究可能会为对p53基因治疗有抗性的肿瘤患者带来新的希望。p53AIP1 has been identified recently as a proapoptotie gene that mediates p53-dependent apoptosis and plays an important role in mediating p53-dependent mitoehondrial apoptosis. Phosphorylation of Ser^46 on p53 regulates the transcriptional activation of this apoptosis-indueing gene. p53AIP1 induces apoptosis effectively in both p53-sensitive and p53-resistant cancer cell lines, p53AIP1 gene can trigger apoptosis directly and might be more widely applicable for treatment of cancer than p53 itself. Thus, p53AIP1 gene therapy could become a new strategy and a useful alternative to p53, especially for the treatment of patients with p53-resistant tumors.

关 键 词：p53AIPl基因 肿瘤抑制 细胞凋亡 

分 类 号：R730[医药卫生—肿瘤]