脑卒中后抑郁症患者事件相关电位N400的研究  

RESEARCH ON EVENT RELATED POTENTIAL IN PANTIENTS WITH POST-STROKE DEPRESSION

作　　者：何文贞[1] 林丽丽[1] 陈妙英[1] 郑璇[1] 

机构地区：[1]汕头大学医学院第一附属医院神经科,广东省汕头市515041

出　　处：《中国煤炭工业医学杂志》2008年第5期617-618,共2页Chinese Journal of Coal Industry Medicine

基　　金：汕头市重大科技项目立项(2004102);广东省社会发展科技计划项目立项(63045)

摘　　要：目的探讨事件相关电位N400在脑卒中后抑郁症中的临床意义。方法按全国第四届脑血管病学术会议制定诊断标准,把我科收治的30例脑卒中后抑郁症(PSD)患者作为观察组,同期随机抽取33例脑卒中后无抑郁症的患者作为对照组,采用MEB-9104K诱发电位仪检测事件相关电位N400,然后利用SPSS11.0软件进行统计学分析。结果PSD组在治疗的不同时期N400的潜伏期:在发病后1d、15d与对照组的1d、15d比较,差异有统计学意义(P<0.05),30d时观察组较对照组延长,但差异无统计学意义。N400的平均波幅:观察组在1d、15d、30d分别与对照组1d、15d、30d比较差异均有统计学意义(P<0.05)。结论PSD患者其事件相关电位N400的潜伏期在治疗前和治疗中较对照组延长,N400的平均波幅在病程的不同时期均较对照组降低。Objective To explore the change of event related potentials（N400）in patients with post - stroke depression （PSD）, Methods There were 30 cases with post - stroke- depression in observation group and 33 non post - stroke- depression patients as controls. The event related potential N400 was detected by ME- 9104k evoked potential detec- tor. Results At different stages, average wave spike latent period of N400 in the observation group was longer than that in the control group during pretherapy and treatment period（P〈0.05）. The average amplitude of wave N400 in the observation group was significantly shorter than that in the control group（P〈0.05）. Conclusion During pretherapy and treatment period, latent period of event related potential of PSD in the observation group is longer than that in the control group.

关 键 词：脑卒中 抑郁症 事件相关电位N400 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]