奥沙利铂联合替加氟方案在鼻咽癌诱导化疗中的应用  

Induction chemotherapy involving L-OHP and UFT for advanced nasopharyngeal carcinoma

作　　者：葛永斌[1] 刘兴京[1] 周涛[1] 谢强[1] 赵荡[1] 

机构地区：[1]武警广东总队医院肿瘤科,广州510507

出　　处：《中国肿瘤临床与康复》2008年第3期241-243,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察奥沙利铂(Oxaliplatin,L-OHP)加替加氟(Tegafur;UFT)联合化疗方案在鼻咽癌诱导化疗中的疗效和毒性。方法41例鼻咽癌患者随机分为两组,分别接受L-OHP+UFT(LT)方案和常规DDP+5-Fu(PF)方案诱导化疗,观察各组的疗效和毒性反应并进行统计学比较。结果LT组和常规PF组的有效率分别为90.0%和85.7%,两组间疗效相似。LT组Ⅲ～Ⅳ度白细胞毒性、恶心呕吐发生率分别为15.0%和25.0%,常规PF组分别为28.6%和38.1%。结论LT方案安全有效,值得在鼻咽癌诱导化疗中推广应用。Objective To evaluate the clinical efficacy and toxicity of induction chemotherapy involving oxaliplatin （L-OHP） and tegafur （UFT） in treatment of advanced nasopharyngeal carcinoma （ NPC ）. Methods Forty-one patients, who were newly diagnosed and pathologically proven as NPC at Ⅲ and Ⅳ a stages ,were randomly assigned to two groups（20 and 21 patients）. All patient characteristics were well balanced between the 2 grouPs. They underwent induction chemotherapy with L-OHP combined with UFT（ LT group） or DDP combined with 5-Fu（ PF group） for 21 days as one cycle respectively. The clinical efficacy and toxicity were evaluated after two cycles. Meanwhile the comparative study was made between the 2 groups. Results Similar clinical complete response rate and partial response rate （90. 0% vs. 85, 7% ） were observed between the 2 groups. However, there were significant differences in incidence of grade Ⅲ and Ⅳtoxicity including leucopenia and vomiting （ 15.0% ,25% in CT group vs. 28.6% ,38. 1% in PF group） between the 2 groups. Conclusions The study indicated that induction chemotherapy with LT is a safe and effective regimen for patients with advanced nasopharyngeal carcinoma.

关 键 词：鼻咽肿瘤 奥沙利铂 替加氟 

分 类 号：R739.63[医药卫生—肿瘤] R730.53[医药卫生—临床医学]