无颌类脊椎动物适应性免疫系统的进化  

The evolution of adaptive immunity system of agnathan vertebrates

作　　者：刘岑杰[1] 黄惠芳[1] 马飞[1] 刘欣[1] 李庆伟[1] 

机构地区：[1]辽宁师范大学生命科学学院,大连116029

出　　处：《遗传》2008年第1期13-19,共7页Hereditas（Beijing)

基　　金：国家自然科学基金(编号:30671083);国家重点基础研究发展计划(编号:2007CB815802)资助~~

摘　　要：适应性免疫系统的起源与进化问题一直是人们研究的热点,以七鳃鳗为代表的无颌类脊椎动物,被普遍认为处在进化出适应性免疫系统的边缘。因此,研究无颌类脊椎动物适应性免疫的机制,对揭示适应性免疫系统的起源与进化具有重要意义。研究表明,无颌类在一定范围内具有高等脊椎动物特有的适应性免疫特征,并发现了一些在结构或功能上与高等脊椎动物免疫相关基因同源的免疫因子。文章就近年来对无颌类脊椎动物适应性免疫系统机制的研究进展作一概述,为进一步深入研究脊椎动物适应性免疫系统的起源与进化提供有益的参考。All along peoples pay extensive attention on the origin and evolution of adaptive immunity system. Agnathans, taking lamprey as the representative, are generally thought at the edge of evolving the adaptive immunity system. Therefore, it is very significantly important to further study the mechanism of adaptive immunity of agnathans for revealing the origin and evolution of adaptive immunity system. Previous studies indicated that agnathans shared some characters of adaptive immunity with higher vertebrates. In addition, a few researchers also found that some genes are homologous in the structure or function with the immunologically relevant genes of higher vertebrates. In this article, we have summarized some recent research progresses about the mechanism of adaptive immunity system of agnathans.The aim of this paper is to provide valuable clues for further studing of the origin and evolution of the adaptive immunity system of vertebrate.

关 键 词：无颌类 适应性免疫 免疫相关基因 起源进化 

分 类 号：Q951[生物学—动物学]