PTEN和p-mTOR在非小细胞肺癌组织中的表达及临床意义  

The expression and clinical significance of PTEN and p-mTOR in non-small cell lung cancer

作　　者：刘红兵[1] 宋勇[1] 吴颖[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院呼吸科,南京210002

出　　处：《临床肿瘤学杂志》2008年第5期397-400,共4页Chinese Clinical Oncology

基　　金：江苏省六大人才高峰基金课题(2005A3)

摘　　要：目的:研究PTEN和p-mTOR蛋白在非小细胞肺癌(NSCLC)组织中的表达和临床意义。方法:运用免疫组化EnVision法检测61例NSCLC和10例非肿瘤肺组织(3例肺结核和7例炎性假瘤)中PTEN和p-mTOR蛋白的表达。结果:PTEN在NSCLC组织中表达的阳性率为27.9%,显著低于对照组(χ2=14.290,P=0.000),并与肿瘤大小明显相关,与性别、年龄、吸烟、病理类型、淋巴结转移情况和pTNM分期无关。p-mTOR在NSCLC组织中表达的阳性率为42.6%,显著高于对照组(χ2=6.725,P=0.010),并与性别、年龄、吸烟、淋巴结转移和pTNM分期相关。PTEN和p-mTOR在NSCLC组织中的表达无显著相关性(r=-0.092,P=0.48)。结论:PTEN在NSCLC组织表达有缺失或减少,mTOR在NSCLC中被激活,PTEN表达的缺失和mTOR激活在NSCLC发生、发展中起到一定的作用,mTOR有望作为抗肿瘤治疗的有效新靶点。Objective：To study the PTEN and p-mTOR expression and clinical significance in non-small cell lung cancer（NSCLC）.Methods：Immunohistochemical staining of Envision was applied to investigate the expression of PTEN and p-mTOR in specimens of 61 NSCLC and 10 non-lung cancer（3 pulmonary tuberculosises and 7 inflammatory pseudotumors）.Results：The postive rate of PTEN was significantly lower in patients with NSCLC（27.9%）than the control（Х^2=14.290,P=0.000）,and was closely correlated with tumor size,but not correlated with age,sex,smoking,lymph node metastasis and pTNM stage.The postive rate of p-mTOR was significantly higher in patients with NSCLC（42.6%）than the control（Х^2=6.725,P=0.010）,and was closely correlated with age,sex,lymph node metastasis and pTNM stage.The expression of PTEN was not significantly correlated with p-mTOR expression in NSCLC（r=-0.092,P=0.48）.Conclusion：The expression of PTEN was absent or decreased.The mTOR actived in NSCLC may be correlated with the absent or decreased of PTEN.The absent or decreased expression of PTEN and the actived mTOR may play important role in carcinogenesis and metastasis of NSCLC.The mTOR may be served as a potential target for anticancer therapy.

关 键 词：PTEN P-MTOR 非小细胞肺癌 预后 临床意义 

分 类 号：R734.2[医药卫生—肿瘤]