一类具有胰岛素增敏作用的苯并吡喃衍生物的设计和合成  

Design and synthesis of a type of benzopyran derivatives with insulin-sensitizing activity

作　　者：汤磊[1] 李煜[1] 俞娟红[2] 杨玉社[2] 嵇汝运[2] 

机构地区：[1]贵阳医学院药学院,贵州贵阳550004 [2]中国科学院上海生命科学研究院上海药物研究所国家新药研究重点实验室,上海201203

出　　处：《药学学报》2008年第6期605-610,共6页Acta Pharmaceutica Sinica

基　　金：贵州优秀科技教育人才省长基金(2005-164);贵州省科学技术基金资助项目(2004-3005).

摘　　要：在化合物1基础上设计合成了10个新型化合物,用3T3-L1前脂肪细胞对这些化合物进行了胰岛素增敏活性筛选。结果表明化合物10在3T3-L1脂肪细胞模型上表现出较强的促3T3-L1细胞分化活性,提示其可能具有较好的胰岛素增敏作用。Ten novel compounds were designed and synthesized on the basis of compound 1, their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Results showed that compound 10 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, which indicated that compound 10 may possess well insulin-sensitizing activity.

关 键 词：胰岛素增敏剂 合成 3T3-L1细胞 

分 类 号：R916.2[医药卫生—药学]