环氧化酶-1在乳腺癌中的表达及其意义  

Expression of cyclooxygenase-1 in human breast cancer and its significance

作　　者：尤捷[1] 郭贵龙[1] 陈雪敏[1] 瞿金妙[1] 张虎祥[2] 王群姬[2] 

机构地区：[1]温州医学院附属第一医院肿瘤外科,325003 [2]温州医学院附属第一医院病理科,325003

出　　处：《实用医学杂志》2008年第10期1707-1709,共3页The Journal of Practical Medicine

基　　金：2005年浙江省温州市科技局立项基金资助项目(编号:Y2005B002)

摘　　要：目的:探讨环氧化酶-1(cyclooxygenase-1,COX-1)在乳腺癌中的表达与临床病理指标之间的相关性,及其对肿瘤血管生成的影响。方法:应用免疫组织化学方法检测61例乳腺癌组织标本的COX-1和血管内皮生长因子(VEGF)的表达。结果:61例乳腺癌组织标本中COX-1阳性率为60.7%,COX-1和VEGF表达明显相关(P=0.026)。在肿块<2cm组以及临床Ⅰ期组中COX-1的表达明显增强(P<0.05)。结论:乳腺癌组织中存在COX-1的高表达,COX-1在乳腺癌的早期阶段可能起着重要作用,VEGF可能是COX-1介导肿瘤新生血管形成的重要因子之一,为非甾体类抗炎药物应用于乳腺癌的预防提供了依据。Objective To study the expression of cyclooxygenase-1 （COX-1） in human breast cancer and its effect on tumor angiogenesis. Methods The expressions of COX-1 and vascular endothelial growth factor （VEGF） were detected in the tissue samples from 61 cases of breast cancer by immunohistochemistry. Results The positive rate of COX-1 expression was 60.7% （37/61） in breast cancer and the expression of COX-1 was significantly associated with that of VEGF（P=0.026）. COX-1 expression was markedly increased in the patients whose tumor size was less than 2 cm or who had stage Ⅰ disease （P 〈 0.05）, Conclusions COX-1 is highly expressed in breast cancer and plays a role in early oncogenesis of the neoplasma. VEGF may be one of the most important factors for angiogenesis in the cancer mediated by COX-1, which provides a clinical support for the use of NSAIDs in prophylaxis of breast cancer.

关 键 词：乳腺肿瘤 环氧化酶-1 血管内皮生长因子 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤] R977.3[医药卫生—临床医学]