葡萄糖转运蛋白1在肝癌组织中的表达与缺氧诱导因子1α表达的关系及临床意义  

Expression of Glut1 and HIF-1α in human hepatocellular carcinoma and its clinical significance

作　　者：梁辉[1] 窦科峰[1] 

机构地区：[1]第四军医大学西京医院肝胆外科

出　　处：《实用医学杂志》2008年第10期1741-1744,共4页The Journal of Practical Medicine

摘　　要：目的:探讨肝细胞癌组织中葡萄糖转运蛋白1(Glut1)和缺氧诱导因子1α(HIF-1α)的表达情况及其临床意义,并分析两者的相关性。方法:用免疫组织化学Envision法检测45例肝细胞癌、11例肝正常组织中Glut1和HIF-1α的表达。结果:Glut1和HIF-1α在肝癌组织中的阳性率明显高于正常肝组织(P<0.05)。在肝癌组织中Glut1和HIF-1α的表达均与肿瘤大小、病理分级、临床分期、有无淋巴结转移、有无门静脉癌栓有关(P<0.05)。肝癌组织中Glut1表达越强,HIF-1α表达也越强,两者的表达呈正相关(r=0.583,P<0.01)。结论:Glut1和HIF-1α的异常表达与肝癌的发生、发展有一定的关系。可能存在HIF-1α通过上调Glut1的表达促进肝细胞癌发生的机制。Objective To investigate the expression and clinical significance of Glutl protein and HIF-1α protein in human hepatocellular carcinoma （HCC）. Methods Immunohistochemical staining Envision method was used to detect the expressions of Glutl and HIF-1α in 45 cases of human hepatocellular carcinoma and 11 cases of normal hepatic tissue. Results The positive expression rate of Glut1 and HIF-1α in human hepatocellular carcinoma was higher than that in normal hepatic tissue （P 〈 0.05）. There was relationship between the expression of Glutl or HIF-1α with tumor size, pathology grade, clinical stage, lymphatic metastasis and portal vein carcino-embolus （all of P 〈 0.05）. With the increase of expression of Glutl, the expression of HIF-1α was increased, between which there was positively correlation （r = 0.583, P 〈 0.01）. Conclusions The variations of Glutl and HIF-1α expressions in human hepatocellular carcinoma may contribute to the pathogenesis and development of the hepatoma. There may be a mechanism that expression of Glutl was up-regulated by HIF-1α, which can facilitate origin of human hepatocellular carcinoma.

关 键 词：癌 肝细胞 单糖转运蛋白质类 DNA结合蛋白质类 免疫组织化学 预后 

分 类 号：R735.7[医药卫生—肿瘤]