食管鳞癌患者血清IGF-1的检测分析  

Detection and Clinical Significance of Serum IGF-1 in Patients with Esophageal Squamous Cell Carcinoma

作　　者：刘新郑[1] 尹惠卿[1] 毛红丽[1] 董见喜[2] 

机构地区：[1]郑州大学第一附属医院检验科,河南郑州450052 [2]郑州大学第一附属医院血液科,河南郑州450052

出　　处：《中国误诊学杂志》2008年第18期4294-4295,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨食管鳞癌患者血清IGF-1的浓度及其临床意义。方法:设立食管鳞癌组合正常对照组。以化学发光法检测65例食管鳞癌患者和30例正常人血清IGF-1的浓度。结果:正常健康人血清IGF-1的含量是(195.35±48.21)ng/ml,食管鳞癌患者为(1 082.29±301.24)ng/ml,明显高于正常对照组(P<0.01),且血清IGF-1水平随临床病理分期的进展而逐步增高(P<0.05)。结论:血清IGF-1有可能作为食管鳞癌诊断或病情监测的一个指标。Objective：To detect the serum insulin like growth factor-1（IGF-1） level in patients with esophageal squamous cell carcinoma and investigate its clinical significance. Methods ： The patient group with esophageal squamous cell carcinoma and the normal control group were designed. The serum IGF-1 level was determined by chemiluminescence assay in 65 esophageal squarnous cell carcinoma patients and 30 normal subjects. Results The level of IGF-1 of patients was （1 082.29±301.24） ng/ml which was higher than that of the normal control group （195.35±48.21） ng/ mi（P〈0. 01）. And the level of IGF-1 also elevated as the clinical pathological tumor stages（P〈0.05）. Concluslons：The serum level of IGF-1 may become one of the serum markers for diagnosis of esophageal squamous cell carcinoma and judgement of the prognosis.

关 键 词：胰岛素样生长因子Ⅰ/血液 食管肿瘤/诊断/血液 癌 鳞状细胞/诊断/血液 肿瘤标记 生物学 人类 

分 类 号：R735.1[医药卫生—肿瘤]