乳腺癌组织抑癌基因PTEN的表达及其意义  

Expression and Significance of the Tumor Suppressor Gene PTEN in Breast Cancer

作　　者：邓军[1] 吴礼高[2] 陈勇[1] 喻大军[1] 

机构地区：[1]安徽省蚌埠医学院附属医院肿瘤外科,233000 [2]蚌埠医学院病理教研室,233000

出　　处：《实用全科医学》2008年第6期555-556,共2页Applied Journal Of General Practice

基　　金：安徽省高校省级自然科学研究项目(KJ2007B378IC)

摘　　要：目的研究抑癌基因PTEN在乳腺癌中的表达及其临床意义。方法采用免疫组化技术(S-P)检测72例乳腺癌中PTEN的表达情况。结果PTEN总的表达缺失率为62.5%(45/72)。PTEN表达缺失率与乳腺癌的组织学分级,TNM临床分期,腋窝淋巴结转移和生存时间有关(P<0.05),而与肿瘤的大小和ER、PR状况无关。结论检测乳腺癌PTEN在蛋白水平的表达缺失状况可能有助于对其预后的判断。Objective To study the expression and clinical significance of tumor suppressor gene PTEN in breast cancer. Methods Immunohistochemieal staining（S-P） was used to detect the expression of PTEN in 72 cases of breast cancer samples. Results Among these 72 samples,the rates of total expressing depletion of PTEN were 62.5% （45/72）. The rates of total expressing depletion of PTEN was significantly correlated with histological grade, TNM staging,axillary lymph nodes status and survival time （ P 〈 0.05 ）, but not with tumor size, estrogen and progesterone receptors. Conclusions The depletion of the expression of PTEN at protein level may contribute to prognostic criterion for breast cancer

关 键 词：抑癌基因PTEN 免疫组织化学 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]