偏执型精神分裂症患者前额叶质子磁共振波谱研究  

H1 Magnetic Resonance Spectroscopy Imaging Study on Prefrontal Lobe in Patients with Paranoid Schizophrenia

作　　者：牟英峰[1] 薛志敏[2] 

机构地区：[1]中南大学湘雅医院神经内科,湖南长沙410008 [2]中南大学湘雅二医院精神卫生研究所,湖南长沙410011

出　　处：《医学临床研究》2008年第5期834-836,共3页Journal of Clinical Research

摘　　要：【目的】探讨偏执型精神分裂症患者前额叶质子磁共振波谱的特点。【方法】应用H1MRS成像技术,对14例偏执型精神分裂症患者以及16名正常对照双侧前额叶的N-乙酰天门冬氨酸复合物(NAA)、胆碱复合物(Cho)和肌酸-磷酸肌酸复合物(Cr)含量进行检测,计算NAA/Cr和Cho/Cr的比值。【结果】患者组左右侧、对照组左右侧NAA/Cr、Cho/Cr比值差异无统计学意义(P>0.05)。患者组、氯氮平组、利培酮组与正常对照组的Cho/Cr比值以及氯氮平组与利培酮组的Cho/Cr、NAA/Cr比值差异均无统计学意义(P>0.05);患者组、氯氮平组以及利培酮组与正常对照组相比,NAA/Cr比值差异有统计学意义(P<0.05),患者组较正常对照组低。【结论】偏执型精神分裂症患者服用非典型抗精神病药后仍然存在前额叶功能减低。[Objective] To measure N-acetylaspartate （NAA）, choline （CHO） and creatine （Cr） in prefrontal cortex of patients with schizophrenia using in vivo proton magnetic resonance spectroscopy imaging （ H^1-MRSI ）. [Methods] H^1-MRSI was performed on the right and left prefrontal cortex in 14 patients with paranoid schizophrenia and 16 normal controls. The ratio of NAA/Cr to Cho/Cr was determined. All data were analyzed by using SPSS13.0, [Results]The NAA/Cr ratio in paranoid schizophrenia patients was significant lower than that in normal controls（ P〈0.05） ,although they were treated with atypical neuroleptics. The CHO/Cr ratio had no significant difference between both groups（ P 〉0.05）. [Conclusion] The neuron function in prefrontal cortex might decrease in paranoid schizophrenia treated with atypical neuroleptics.

关 键 词：精神分裂症 偏执型/诊断 磁共振波谱学 

分 类 号：R749.3[医药卫生—神经病学与精神病学]