姜黄素类化合物及姜黄素衍生物对酪氨酸酶抑制作用的研究  

Study of inhibition of curcuminoids and curcumin derivatives on tyrosinase

作　　者：杜志云[1] 徐学涛[1] 潘文龙 韦星船[1] 张焜[1] 

机构地区：[1]广东工业大学轻工化工学院,广东广州510006 [2]中国广州分析测试研究中心,广东广州510070

出　　处：《日用化学工业》2008年第3期172-175,共4页China Surfactant Detergent & Cosmetics

基　　金：广东省科技计划资助项目(2007A020300007-10)

摘　　要：从中药姜黄的提取物中分离了姜黄素、单去甲氧基姜黄素及双去甲氧基姜黄素,并对姜黄素进行了引入羧酸基团、乙酰化、氢化等结构修饰,合成了4个姜黄素衍生物,并测试了这些化合物对酪氨酸酶的抑制活性。结果表明,天然姜黄素类化合物中单去甲氧基姜黄素的活性最强,IC50为0.076 mmol/L;姜黄素的结构修饰化合物中,带羧基的姜黄素衍生物表现出很强的抑制活性,IC50为0.056 mmol/L。抑制动力学研究表明,单去甲氧基姜黄素及带羧基的姜黄素衍生物对酪氨酸酶的抑制均属于非竞争性抑制类型。Curcumin, mono -demethoxycurcumin and bis -demethoxycurcumin were isolated from the extract of curcuma longa （turmeric）, and four curcumin derivatives were prepared by carboxylation,acetylation and hydrogenation of curcumin. Curcuminoids and curcumin derivatives were evaluated for tyrosinase inhibition activity. The results showed that among the natural curcuminoids, mono - demethoxycurcumin shows the highest inhibition activity on tyrosinase of IC50 = 0. 076 mmol/L. While among the curcumin derivatives, the carboxylized curcumin shows strong tyrosinase inhibition activity of IC50 = 0. 056 mmol/L.Kinetic studies showed that the mechanism of tyrosinase inhibition of both mono - demethoxycurcumin and carboxylized curcumin belongs to non- competitive type inhibition.

关 键 词：化妆品添加剂 姜黄素 姜黄素类化合物 姜黄素衍生物 酪氨酸酶 抑制 

分 类 号：R285[医药卫生—中药学]