不同复苏方式对失血性休克复苏后大鼠腹腔感染时TNF-α和IL-6的影响  

Effects of different means of resuscitation on TNF-α and IL-6 in rats with abdominal infection after hemorrhagic shock

作　　者：王宏[1] 段绍斌 姚华[3] 李广学 刘郁[1] 张增峰[1] 马林杰[1] 

机构地区：[1]新疆医科大学中医学院 [2]新疆维吾尔自治区中医医院普外科 [3]新疆医科大学公共卫生学院,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2008年第4期466-468,共3页Journal of Xinjiang Medical University

摘　　要：目的:研究不同复苏方式对失血性休克复苏后大鼠腹腔感染时肿瘤坏死因子(TNF-α)和白细胞介素-6(IL-6)的影响。方法:将46只SD大鼠随机分为限制性液体复苏组和快速大量液体复苏组,观察复苏后2组大鼠的出血量、输液量、存活率;复苏后在腹腔注入内毒素,再将2组大鼠各随机分为2组,分别于2h、4h测定血清中的TNF-α和IL-6水平。结果:限制性液体复苏组的输液量及出血量明显少于快速大量液体复苏组,2组存活率比较差异有统计学意义(P<0.05);限制性液体复苏组大鼠的TNF-α和IL-6水平均低于相同时间点的快速大量液体复苏组(P<0.05)。结论:限制性液体复苏可明显降低出血量及死亡率,同时在复苏后继发腹腔感染时,限制性液体复苏可以降低大鼠的TNF-α和IL-6水平。Objective： To observe the effects of different means of resuscitation on TNF-α, IL-6 in rats with abdominal infection after hemorrhagic shock. Methods： Rat models of hemorrhagic shock were reproduced using the modified Capone methods. Fourty six SD rats were randomly divided into two groups： Limited fluid resuscitation group, large quantity fluid rapid resuscitation group （each n = 23）. Then the blood of loss and the amount of fluid resuscitation, survival rate were observed. Then each group were randomly divided into two different time points abdominal injection of LPS, the contents of TNF-α and IL-6 were measured in 2 h and 4 h. Results： The blood loss and the amount of fluid resuscitation in limited fluid resuscitation group was significantly lower than that in large quantity fluid rapid resuscitation group. The contents of TNF-α and IL-6 of the limited fluid resuscitation group were lower than those in large quantity fluid rapid resuscitation group at the same time （P 〈0. 05）. Conclusion： The limited fluid resuscitation could obviously reduce the blood loss and mortality, while secondary recovery after abdominal infection, limited fluid resuscitation can reduce the rats TNF-α, IL-6 levels.

关 键 词：休克 复苏 腹腔感染 TNF-Α IL-6 

分 类 号：R-332[医药卫生] R363