卵巢上皮性肿瘤相关凋亡调控基因的研究进展  

Study Progress of Apoptotic Controlling Gene Related to Ovarian Epithelial Tumor

作　　者：王红霞[1] 陈钢[1] 李国利[1] 

机构地区：[1]扬州大学医学院病理学教研室,江苏扬州225001

出　　处：《医学综述》2008年第11期1655-1657,共3页Medical Recapitulate

摘　　要：卵巢上皮性肿瘤为常见的妇科肿瘤,其发生、发展是由癌基因的激活、抑癌基因的失活、凋亡调控机制的紊乱等多步骤参与的复杂过程,其中凋亡调控机制的紊乱是很重要且被密切关注的一个环节。肿瘤细胞的凋亡抑制和过度增殖加速了肿瘤的恶性进展。因此,文章选择了Bcl-2、Bax、Survivin、Smac、Fas这5个具有代表性、关键性的凋亡调控基因来描述它们在卵巢上皮性肿瘤中的表达情况及演变规律。Ovarian epithelial tumor is the common gynecological tumor,the occurrence and development of ovarian epithelial tumor is a complicated process including many steps,such as activation of oncogenes,deactivation of anti-oncogene,dysfunction of apoptotic regulatory mechanism and so on.And the apoptotic regulatory mechanism is the very important linkage attracting moer attention.Apoptotic suppression and over proliferation of tumor cells can accelerate the progressing of malignant tumor.So,this article not only reviews five key apoptotic regulatory genes with representativeness,including Bcl-2,Bax,Survivin,Smac and Fas,but also describes their expression and developing rule in ovarian epithelial tumor.

关 键 词：卵巢上皮性肿瘤 BCL-2/BAX Survivin SMAC Fas 

分 类 号：R737.31[医药卫生—肿瘤]