原发性肝癌TACE前后sICAM-1的动态变化及其意义  

Change and Significance of Soluble Intercellular Adhesion Molecule-1 in Hepatocellular Carcinoma Patients before and after Transcatheter Arterial Embolization

作　　者：李海利[1] 陈济铭[1] 陈仲武[1] 陈一平[1] 郑山[1] 黄永昇[1] 林秀华[1] 

机构地区：[1]福建医科大学附属第一医院影像科介入室,福州350005

出　　处：《医学综述》2008年第11期1736-1738,共3页Medical Recapitulate

摘　　要：目的检测原发性肝癌患者经肝动脉插管化疗栓塞(TACE)前后血清细胞间黏附分子1(sICAM-1)的动态变化,探讨sICAM-1与肿瘤活性的关系。方法运用酶联免疫吸附试验方法测定36例原发性肝癌患者第1次TACE术前、术后3d、7d及术后1个月血清ICAM-l的水平。结果TACE术前原发性肝癌患者sICAM-1的水平(647.94±95.69)μg/L明显高于健康对照组sICAM-1的水平(201.07±68.81)μg/L,差异有统计学意义(P<0.01),术前sICAM-1水平在不同甲胎蛋白含量各组间无明显差异(P>0.05)。术后3dsICAM-1的水平(567.85±99.79)μg/L与术后7dsICAM-1的水平(542.84±89.94)μg/L较术前显著下降(P<0.01),并且术后7d低于3d的slCAM-1水平(P=0.022),术后1个月sICAM-1水平与术前相比差异无统计学意义(P=0.124)。术后1个月sICAM-1水平减少率在碘油沉积良好组(16/18)中与碘油沉积不良组(2/10)间存在显著差异(P<0.01)。结论sICAM-1水平的变化与肿瘤活性密切相关,对判断原发性肝癌患者,尤其在甲胎蛋白阴性的患者再次TACE的指征及评价TACE效果方面有一定的价值。Objective To observe the changes of serum soluble intercellular adhesion molecule-1（slCAM-1）in patients with hepatocellular carcinoma（HCC）before and after transcatheter arterial chemoembolization（TACE）and to identify clinical significance of serum sICAM-1 in estimating the activity of the tumour.Method Serum sICAM-1 in patients with HCC were detected by ELISA before the first TACE,3 days after TACE,7 days after TACE and 1 month after TACE respectively.Results Compared with control group（201.07±68.81）μg/L,the level of serum sICAM-l in patients with HCC before the first TACE（647.94±95.69）μg/L increased significantly（P〈0.01）.The level of serum sICAM-l had not significant difference in patients with HCC before the first TACE between different AFP groups.The level of serum sICAM-l declined remarkably 3 after TACE,7 days after TACE（567.85±99.79 μg/L,542.84±89.94 μg/L,respectively）.and the level of serum sICAM-l of 7 days is lower than the level of serum sICAM-l of 3 days after TACE（P=0.022〈0.05）.The level of serum sICAM-l had not significant difference between 1 month after TACE and before TACE in patients with HCC（P=0.124〉0.05）.Significant difference was found in the reduction rate of sICAM-1 between the group which the iodine oil deposition is good and the group which is bad 1month after the operation.（16/18,2/10,respectively,P〈0.01）.Conclusion It can be concluded that slCAM-1 levels in patients with liver carcinoma were closely related to the activity of the tumour.The changes of serum sICAM-1 are valuable in estimating the prognosis after TACE and evaluating the indication of re-TACE treatment in patients with HCC especially those AFP are negative.

关 键 词：肝肿瘤 化疗栓塞 可溶性细胞间黏附分子1 

分 类 号：R730.3[医药卫生—肿瘤] R735.7[医药卫生—临床医学]