β-catenin与cyclinD1在乳腺癌中的表达及其意义  

Expression and significance of β-catenin and cyclinD1 in breast carcinoma

作　　者：董晓[1] 房新志[2] 柴敏秀[2] 李景英[2] 

机构地区：[1]新疆医科大学基础医学院病理学教研室,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院病理科,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2008年第5期541-543,547,共4页Journal of Xinjiang Medical University

摘　　要：目的：探讨β-连环蛋白（β-catenin）和细胞周期蛋白D1（cyclinD1）在乳腺癌中的表达及其意义。方法：采用免疫组织化学染色法检测65例乳腺癌组织中pcatenin和cyclinD1的表达，并分析不同临床病理学参数患者pcatenin和cyclinD1的表达情况。结果：42例（64．62％）乳腺癌组织中B～catenin呈异常表达，不同肿瘤直径大小（≤2cm、〉2cm）、年龄（〈50岁、≥50岁）、病理学分级（G1、G2、G3）、TNM分期（Ⅰ、Ⅱ、Ⅲ期）及雌激素受体（ER）、孕激素受体（PR）状态（＋、-）乳腺癌患者β-Catenin表达差异有统计学意义（P〈0．05～0．01）；30例（46．15％）乳腺癌组织中cyclinD1呈阳性表达，不同病理学分级、TNM分期、淋巴结有无转移、PR状态乳腺癌患者cyclinD1表达差异有统计学意义（P〈0．05～0．01）。cyclinD1阳性患者β-Catenin异常表达率较cyclinD1阴性患者显著增高（P〈0．05）。结论：β-catenin的异常表达与乳腺癌进展和转移有关，其机制可能是通过激活cyclinD1基因的表达，促使细胞增殖和恶性转化而实现。Objective： To investigate the expression and the significance of β-catenin and cyclinD1 in breast carcinoma. Methods： Using immunohistochemical staining technique to detect the expression of β-catenin and cyclinD1 in 65 cases of breast carcinoma tissue samples, and studying their expression in cases with different clinical patho-parameter. Results： The aberrant expression of β-catenin was found in 42 cases （64.25%）, the significant difference in the rate of β-catenin positive expression was found respectively in different tumor size （P 〈0.01）, in different age （P 〈0.01）, in different pathological grading （P〈0.05）, in different TNM-classification tumor（P〈0.01）, in different ER expression （P 〈0.01） and PR expression （P〈0.01）. The overexpression of cyclinD1 was found in 30 cases（46. 15%）, the significant difference was found in different pathological grading, in different TNM-classification tumor, in different lymph node metastasis status and in different PR expression （P〈0.01）. The aberrant expression of β-catenin in the patients with overexpression of cyclinD1 is higher than others significantly （P 〈0.05～0.01）. Conclusion： The aberrant expression of β-catenin is related with the progression and metastasis of breast carcinoma through the activation of an cyclinD1 gene activation and inducing the tumor cell proliferation and malignant transformation.

关 键 词：乳腺癌 Β-连环蛋白 细胞周期蛋白D1 

分 类 号：R730.3[医药卫生—肿瘤] R737.9[医药卫生—临床医学]