15例子宫内膜浆液性乳头状癌临床资料分析  

Clinical analysis of 15 cases of uterine papillary serous carcinoma

作　　者：王丽霞[1] 唐丽云[1] 

机构地区：[1]大连医科大学附属第二医院妇产科,辽宁大连116027

出　　处：《大连医科大学学报》2008年第3期260-262,共3页Journal of Dalian Medical University

摘　　要：[目的]探讨子宫内膜浆液性乳头状癌（uterine papillary serous carcinoma,UPSC）的临床病理特征以及合理的治疗方法。[方法]对1995年1月-2007年12月收治的15例UPSC患者进行回顾性研究,对其发病趋势、危险因素、临床表现、病理特征、诊断方法和治疗方案进行分析。[结果]平均发病年龄63.8岁,80%患者雌孕激素受体阴性,53.3%患者术后手术病理分期高于术前临床分期,P53在60%患者中有表达,中晚期患者血清CA-125水平均有升高。所有患者均接受手术治疗,多数术后辅助化疗、放疗,生存率仍较低。[结论]UPSC不同于子宫内膜样腺癌,具有其特殊性,恶性程度较高,预后差。合理的个体化综合治疗可提高生存率。[ Objective ] To investigate the clinical and pathologic characteristics, and search the rational therapy for uterine papillary serous carcinoma （ UPSC ）. [ Methods ] A retrospective study was conducted on incidence, risk factors, clinical characters, pathological feature, diagnosis and treatment of 15 patients with UPSC, who was admitted from Jan. 1995 to Dec. 2007. [ Results] Median age at diagnosis was 63.8 years. Among all the patients with UPSC, 80% presented negative estrogen and/or progestin receptor,53.3% diagnosed as higher stage post operative than preoperative staging;and 60% presented positive P53 . The level of CA - 125 in serum elevated among middle - late stage patients. All the patients underwent operation, and a great part received postoperative radiotherapy and/or chemotherapy. The survival rate was still lower. [ Conclusion ] UPSC is highly malignant, which has different clinical and pathological characteristics from the endometrioid carcinoma. Rational individualized treatment may lengthen survival time.

关 键 词：子宫内膜浆液性乳头状癌 临床病理 治疗 

分 类 号：R737.33[医药卫生—肿瘤]