乳腺腺肌上皮瘤的临床病理学观察  

Clinicopathological features of breast adenomyoepithelioma

作　　者：高晓磊[1] 耿建祥[1] 徐文华[1] 黄书亮[1] 张鸿莺[1] 王琴[1] 韩惦梅[1] 

机构地区：[1]南京中医药大学附属南京市中医院病理科,南京210001

出　　处：《临床与实验病理学杂志》2008年第2期162-165,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨乳腺腺肌上皮瘤的临床病理诊断、治疗和预后。方法应用光镜及免疫组化染色对5例乳腺腺肌上皮瘤进行临床病理诊断、分型、治疗及预后分析,同时复习相关文献。结果5例均发生于女性,均为良性肿瘤,年龄29-37岁,平均33.2岁。1例为实体型,1例为腺管型,3例为小叶型。镜下见肿瘤由增生的腺上皮和肌上皮两种成分构成,前者构成管状结构的内层,后者构成管状结构的外层以及实性区域。前者表达CK、EMA、MUC-1,后者表达SMA、S-100、p63、Calponin。随访5例6-12年肿瘤均无复发或转移。结论乳腺AME是一种罕见而独特的病变,多数属于良性肿瘤,预后通常较好,手术仍是最好的治疗手段,其诸多方面的问题尚有待于进一步探讨。Purpose To study the clinicopathological diagnosis and treatment of adenomyoepithelioma of the breast. Methods Five cases of adenomyoepithelioma of the breast were studied by microscopy and immunohistochemistry, with review of related literature. Results Five cases all were benign adenomyoepitheliomas and occurred in women, with age ranged from 29 to 37 （average 33. 2 years）. One case was solid （papillary） subtype, 1 case was tubular subtype and 3 cases were lobular subtypes among the 5 cases in this study. The tumors had distinct components of epithelial and myoepithelial cells, the fomer lined the lumina of the tubular structures, while the latter constituted the outer layer of the tubular structures and the solid areas, the immunohistochemical staining showed the former was positive for CK, EMA, MUC-1, and that of the latter was positive for SMA, S-100, p63, and calponin. Follow-up in 5 cases for a period of 6 to 12 years revealed free of recurrences or metastases. Conclusions Adenomyoepithelioma of the breast is a rare and distinct entity, and most of breast adenomyoepitheliomas are benign but further study is needed.

关 键 词：乳腺肿瘤 腺肌上皮瘤 肌上皮细胞 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]