氯离子对东方拟无枝酸菌发酵产物的影响  

The effect of chlorine on the fermentation products of Amycolatopsis orientalis

作　　者：周雨朦[1] 洪文荣[1] 阮林高[2] 陈代杰[2] 戈梅[1] 

机构地区：[1]福州大学生物科学与工程学院,福州350002 [2]上海来益生物药物研发中心,上海201203

出　　处：《中国抗生素杂志》2008年第5期273-275,292,共4页Chinese Journal of Antibiotics

摘　　要：本文研究了氯离子对东方拟无枝酸菌发酵产物的影响。在常规培养条件下,改变发酵培养基中氯离子存在形式或是添加抑氯剂和溴化钠,都发现了新组分无氯万古霉素(didechlorovancomycin,DDCV)的产生。通过对培养基中添加抑氯剂的量的改变,发现加入0.005%2-巯基苯骈噻唑和0.1%溴化钠时万古霉素产量降至对照的6%,而DDCV的相对含量达到62%。This study focused on the effect of chorine on the fermentation products of Arnycolatopsis orientalis. Changing the form of inorganic salt of Chloride anion or adding its inhibitor and NaBr into the medium, a new component didechlorovancomycin （DDCV） was found. An optimum fermentation medium was obtained in which 0. 005% inhibitor and 0.1% NaBr was added, while the vancomycin yield decreased to 6%, and the relative content of didechlorovancomycin was reached up to 62% as compared to the control respectively.

关 键 词：无氯万古霉素 抑氯剂 溴化钠 

分 类 号：Q891[生物学]