检测肺癌患者胸腔积液中CEA及CA153的临床意义(附56例报告)  

Expression and signif icance of CEA and CA153 in pleural fluid of patients with lung cancer

作　　者：潘桂梅[1] 张恒彬[2] 

机构地区：[1]哈尔滨二四二医院,黑龙江哈尔滨150066 [2]绥滨县人民医院,黑龙江绥滨156200

出　　处：《哈尔滨医药》2008年第3期11-12,共2页Harbin Medical Journal

摘　　要：目的本研究拟通过检测肺癌患者血清和胸腔积液中癌细胞释放的癌蛋白,以弥补单纯细胞学检测的局限性,寻找一种更灵敏、准确的肺癌检测手段。方法采用电化学发光分析仪对56例肺癌患者及32例非肺癌患者的血清和胸腔积液进行了免疫蛋白定量分析。结果肺癌组明显高于非肺癌组内水平(P<0.01),CEA与CA153联合检测为最佳组合,其敏感性和特异性分别高达87.61%和97.8%。结论检测肺癌患者胸腔积液中CEA及CA153水平可能对肺癌的诊断具有重要的临床意义。Objective In order to enhance the diagnostic rate of pleural fluid with lung cancer, carcinoembry-onic antigen （CEA） and cancer antigen 153 （CA153） were detected in serumand pleural fluid,and their diagnostic values on lung cancer were analyzed. Methods Quantities of CEA andCA153 weredetectedbyelecteo - chemical luminescence in both serum and pleural fluid of patient s with lung cancer （56 ca2ses） and without lung cancer （32 cases）. Results The levels of lung cancer were significantly higher than those without lung cancer （P 〈0.01 ）, The optimal diagnostic assay of lung cancer was CEA ＋ CA153 combination ： sensitivity and specificity were 87.6 1% and98.7% respectively. Conclusion It could be of important clinical significance for diagnosing lung cancer by as saying CEA and CA153 in pleural fluid of patient s with lung cancer.

关 键 词：肺肿瘤 胸腔积液 细胞诊断学 电化学发光 

分 类 号：R734.2[医药卫生—肿瘤]