一氧化氮在脑缺血再灌流神经损伤中作用的实验研究  

Studies of nitric oxide effecting on the neuronal damage after reperfusion following global cerebral ischemia

作　　者：李恩民[1,2] 吕晓红 许丽艳[1,2] 欧阳一冰[1,2] 王桂侠 饶明俐[1,2] 杨同书 

机构地区：[1]白求恩医大应用基础医学研究所 [2]白求恩医大一院神经内科

出　　处：《中风与神经疾病杂志》1997年第6期333-335,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：采用改良的Ｇｒｉｅｓｓ法，测定了脑缺血再灌流大鼠血清和脑组织中一氧化氮（ＮＯ）代谢产物ＮＯｘ（ＮＯ２＋ＮＯ３）的含量。结果表明，在脑缺血再灌流过程中实验大鼠血清和脑组织中ＮＯｘ含量的变化表现出独特的双峰现象，其第二高峰的出现时间与迟发性神经元损伤的发生相吻合。这提示，ＮＯ在脑缺血再灌流神经损伤中可能具有重要作用。NO_x (NO_2+NO_3) content,which are nitric oxide (NO) meta,in the serum and brain tissue of rats with after reperfusion following cerebral ischemia was measured with improved Griess method.The results showed that the change of NO_xcontent had a twohumped characteristic,and the second appeared peak consistented with happened delayed neuronal damage.These determined NO is of significance in the neuronal damage after reperfusion following ischemia.

关 键 词：一氧化氮 脑缺血 再灌注损伤 动物实验 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R364.12[医药卫生—临床医学]