Effect of Lidan Granule(利胆冲剂) on Bile Lithogenesis in Patients with Choledocholithiasis Combined with Cholecystolithiasis  

作　　者：向阳 陈进宏 蔡端 马保金 

机构地区：[1]Department of General Surgery Huashan Hospital of Fudan University

出　　处：《Chinese Journal of Integrative Medicine》2008年第2期142-144,共3页中国结合医学杂志（英文版）

摘　　要：ABSTRACT Objective： To observe the effect of Lidan Granule （利胆冲剂, LDG） on bile lithogenic tendency and biliary 33.5 kd vesicular protein （VP） and to explore its mechanism. Methods： Sixty patients with choledocholithiasis combined with cholecystolithiasis were randomly assigned to the LDG treated group, the sodium cholate treated group for positive control, and the untreated control group, 20 patients in each group. The 4 bile lithogenic trend indexes, including lithogenic index （LI）, unconjugated bilirubin percent （UCB%）, unconjugated bilirubin saturation index （BSI） and Z-value, were determined before and after treatment. The content of VP in bile was determined as well. Results： Before treatment, the LI, UCB%, BSI and Z-value in the LDG treated group were 1.298 ± 0.265, 34.72 ± 2.96, 0.353± 0.093 and 0.556 ± 0.499, respectively, which was decreased after the 2-week treatment to 0.926± 0.208, 8.93± 1.19, 0.154 ± 0.056 and 0.257± 0.211, respectively （all P〈0.05）. Meantime, the content of VP was also lowered from 0.050 ± 0.005 g/L to 0.032 ± 0.005 g/L. However, no significant change in any of the above-mentioned indexes was found in the other two groups. Conclusion： LDG could effectively suppress bile lithogenic trend and reduce 33.5 kd VP in bile.ABSTRACT Objective： To observe the effect of Lidan Granule （利胆冲剂, LDG） on bile lithogenic tendency and biliary 33.5 kd vesicular protein （VP） and to explore its mechanism. Methods： Sixty patients with choledocholithiasis combined with cholecystolithiasis were randomly assigned to the LDG treated group, the sodium cholate treated group for positive control, and the untreated control group, 20 patients in each group. The 4 bile lithogenic trend indexes, including lithogenic index （LI）, unconjugated bilirubin percent （UCB%）, unconjugated bilirubin saturation index （BSI） and Z-value, were determined before and after treatment. The content of VP in bile was determined as well. Results： Before treatment, the LI, UCB%, BSI and Z-value in the LDG treated group were 1.298 ± 0.265, 34.72 ± 2.96, 0.353± 0.093 and 0.556 ± 0.499, respectively, which was decreased after the 2-week treatment to 0.926± 0.208, 8.93± 1.19, 0.154 ± 0.056 and 0.257± 0.211, respectively （all P〈0.05）. Meantime, the content of VP was also lowered from 0.050 ± 0.005 g/L to 0.032 ± 0.005 g/L. However, no significant change in any of the above-mentioned indexes was found in the other two groups. Conclusion： LDG could effectively suppress bile lithogenic trend and reduce 33.5 kd VP in bile.

关 键 词：Lidan Granule BILE lithogenic trend vesicular protein 

分 类 号：R26[医药卫生—中医外科学]